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Found 12 clinical trials
Flexible-Dose Trial in Early Parkinson's Disease (TemPo-2)

The purpose of this study is to assess the efficacy, safety, tolerability and pharmacokinetics (PK) of flexible doses of tavapadon in participants with Parkinson's Disease.

dopamine
dopamine agonists
levodopa
dopa
bradykinesia
  • 8 views
  • 31 Jul, 2021
  • 49 locations
Fixed-Dose Trial in Early Parkinson's Disease (TemPo-1)

The purpose of this study is to evaluate the clinical efficacy, safety and pharmacokinetics (PK) of 2 fixed doses of tavapadon and placebo in participants with early Parkinson's Disease.

dopamine
dementia
tremor
mao-b inhibitor
cognitive impairment
  • 19 views
  • 12 Sep, 2021
  • 79 locations
Early ParkinSon wIth L-DOPA/DDCI and OpicapoNe (EPSILON Study)

Opicapone (OPC) is a third generation catechol O methyltransferase (COMT) inhibitor (COMTi) developed by BIAL-Portela & C, S.A. It is approved as adjunctive therapy to preparations of L-DOPA/DDCI in adult patients with Parkinson's disease and end-of-dose motor fluctuations who cannot be stabilized on those combinations. Carbidopa and benserazide are both …

  • 0 views
  • 04 Aug, 2021
  • 1 location
PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706

The study is conducted to evaluate the efficacy, safety, and tolerability of two doses of K0706 compared to placebo in subjects with early Parkinson's Disease who are not receiving dopaminergic

early parkinson's
  • 148 views
  • 28 Jun, 2021
  • 138 locations
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease

REM Behavior Sleep Disorder (RBD) is a sleep disorder causing people to 'act out' their dreams. A high percentage of individuals with idiopathic RBD (iRBD) are known to develop conditions affecting the neurons in the brain such as Parkinson's disease (PD). Based on the increased risk to develop PD, individuals …

dopamine
tremor
SPECT Scan
metaiodobenzylguanidine
loss of smell
  • 9 views
  • 07 Aug, 2021
  • 1 location
Terazosin Effect on Cardiac Changes in Early Parkinson's Disease

REM Behavior Sleep Disorder (RBD) is a sleep disorder causing people to 'act out' their dreams. A high percentage of individuals with idiopathic RBD (iRBD) are known to develop conditions affecting the neurons in the brain such as Parkinson's disease (PD). Based on the increased risk to develop PD, individuals …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease

early Parkinson's disease(PD) patients. Here the investigators design a multicenter, randomized, double-blind, placebo-controlled, delayed-start trial to evaluate the effects of Lingzhi on modifying

early parkinson's
levodopa
antiparkinsonian agents
  • 1 views
  • 05 Sep, 2021
  • 1 location
A Clinical Study of NLY01 in Patient's With Early Parkinson's Disease

This is a phase 2 study designed to assess the safety, tolerability and efficacy of NLY01 in subjects with early untreated Parkinson's disease (PD). Evidence suggests NLY01, a pegylated form of exenatide, may be beneficial in PD and is being developed as a potential treatment for neurodegenerative disorders. For more …

  • 1 views
  • 16 Apr, 2021
  • 46 locations
A Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's Disease

NOPARK is a double-blinded randomized controlled trial that studies nicotinamide supplementation in early Parkinson's disease. Parkinson's disease (PD) is a major cause of death and

early parkinson's
datscan
malnutrition
  • 20 views
  • 24 Jan, 2021
  • 8 locations
A Study to Determine the Dose of WIN-1001X by Evaluating Efficacy and Safety in Early Parkinson's Disease Patients

conducting a therapeutic exploratory study on three dose groups of WIN-1001X 400 mg, 800 mg, and 1200 mg, and placebo group in patients with early Parkinson's disease.

dopamine
mental state examination
early parkinson's
mini-mental state examination
dopamine transporter
  • 2 views
  • 08 Mar, 2021
  • 1 location