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Found 778 clinical trials
Combined Breast MRI and Biomarker Strategies in Identifying High-risk Breast Cancer Patients

This clinical trial studies normal breast tissue changes combined with breast magnetic resonance imaging (MRI) that may suggest the beginnings of cancer development. Using breast tissue markers in combination with breast imaging such as MRI may help to more accurately assess a woman's risk of developing breast cancer.

cancer
Accepts healthy volunteers
  • 366 views
  • 03 Dec, 2021
  • 5 locations
Motor Language Learning (MOTOLANGUAGE)

This project pursues the validation of an innovative strategy to boost language learning, based on the benefits derived from sensorimotor training. The common belief of a rigid brain structure in adult life had to be reconsidered during the last decade. After training, local increase in cerebral cortex volume and thickness, …

Accepts healthy volunteers
  • 118 views
  • 06 Apr, 2022
  • 1 location
Self-sampling for Non-attenders to Cervical Cancer Screening (KOPRETINA)

The trial will evaluate whether self-sampling and human papillomavirus (HPV) testing may increase cervical cancer screening attendance among under-screened women in Czech Republic. Different ways of offering self-sampling device will be evaluated.

diagnostic procedures
human papillomavirus
cancer
Accepts healthy volunteers
human papilloma virus vaccine
  • 16 views
  • 22 Mar, 2022
  • 1 location
Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer(CITRINE) (CITRINE)

This is a prospective, single center, randomized, open-labled stage III clinical trial comparing the efficacy and safety of anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel combined with carboplatin for high-risk, triple-negative early breast cancer.

triple negative breast cancer
paclitaxel
carboplatin
erbb2
cancer
  • 20 views
  • 28 Feb, 2022
  • 1 location
Integrated Cervical Cancer Screening in Mayuge District Uganda (ASPIRE Mayuge) (ASPIRE)

The purpose of this pragmatic cluster randomized control trial is to test the effectiveness of cervical cancer screening follow-up completion using two implementation approaches for self-collected HPV testing in a rural, low-resource setting: 1) community health workers recruiting women door-to-door and 2) community health workers recruiting women at community health …

hysterectomy
cervical cancer screening
cancer screening
cancer
Accepts healthy volunteers
  • 0 views
  • 05 Mar, 2022
  • 1 location
A Phase 3 Study Comparing Carelizumab Plus Nab-paclitaxel and Apatinib Carelizumab Plus Nab-paclitaxel and Nab-paclitaxel in Patients With Advanced Triple Negative Breast Cancer.

This randomized, open-label phase 3 study will evaluate the safety and efficacy of Carelizumab (an engineered anti-programmed death-ligand 1 [PD-1] antibody) in combination with Nab-paclitaxel and Apatinib, carelizumab plus nab-paclitaxel, and Nab-paclitaxel in Patients with Unresectable Locally Advanced or Metastatic Triple Negative Breast Cancer. Participants will be randomized in a …

triple negative breast cancer
paclitaxel
erbb2
cancer
measurable disease
  • 10 views
  • 24 Jan, 2021
  • 1 location
A Study of Camrelizumab Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC)

The purpose of this study is to evaluate the efficacy and safety of camrelizumab (an engineered anti-programmed death-ligand 1 [PD-1] antibody) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy in participants with triple negative breast cancer (TNBC). Participants will be randomized in a 1:1 ratio to Arm A (camrelizumab …

triple negative breast cancer
HER2
erbb2
  • 0 views
  • 21 Mar, 2022
  • 1 location
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer (SASCIA)

Phase III, prospective, multi-center, randomized, open label, parallel group, study in patients with HER2-negative breast cancer with residual disease after neoadjuvant chemotherapy with 1:1 allocation to: Arm A: Sacituzumab govitecan (days 1, 8 q3w for eight cycles); Arm B: treatment of physician´s choice (TPC, defined as capecitabine or platinum-based chemotherapy …

anthracyclines
core needle biopsy
capecitabine
taxane
carboplatin
  • 8 views
  • 28 Apr, 2022
  • 49 locations
Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers

A prospective multicenter randomized non-inferiority clinical trial, to evaluate the efficacy and safety of 1.0 cm-safety margin surgery, compared with 1.5 cm safety margin surgery for cT1-2N0 oral tongue cancer Summary A current standard primary treatment for oral tongue cancer is a curative surgical resection with/without adjuvant radiation treatments (or …

  • 0 views
  • 12 May, 2022
  • 1 location
Toripalimab in Combination With Nab-Paclitaxel For Patients With Metastatic or Recurrent Triple-Negative Breast Cancer (TNBC) With or Without Systemic Treatment (TORCHLIGHT)

This multicenter, randomized, double-blind study will evaluate the efficacy and safety of Toripalimab (JS001) combined with nab-paclitaxel compared with placebo combined with nab-paclitaxel for first/second line treatment of metastatic or recurrent triple-negative breast cancer (TNBC).

taxane
cancer
measurable disease
progesterone
mammogram
  • 48 views
  • 10 May, 2022
  • 68 locations