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Found 759 clinical trials
Clinical Study Relating to Patients Undergoing Medial Femoral Patellar Ligament Reconstruction

The objective of the present study will be to evaluate the clinical patellofemoral joint function (primary endpoint) and radiographically the patellofemoral arthritic degeneration (secondary endpoint) of of MPFL reconstruction with fascia lata allograft at a minimum follow-up of 2, 5 and 10 years in a group of 25 patients.

  • 25 Feb, 2022
  • 1 location
Intraamniotic Administrations of ER004 to Male Subjects With X-linked Hypohidrotic Ectodermal Dysplasia (EDELIFE)

This is an open-label, prospective, genotype-match controlled for primary estimand, non randomized, multicenter, international Phase 2 clinical trial designed to investigate the efficacy and safety of ER004 administered intraamniotically as a treatment for unborn XLHED male subjects.

  • 28 Jun, 2022
  • 5 locations
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE (ESOGUARDBE1)

and without dysplasia, and/or Esophageal Adenocarcinoma, in individuals deemed to be at high risk for these conditions (i.e., screening) per ACG guidelines.

gastroesophageal reflux
Accepts healthy volunteers
gastroesophageal reflux disease
  • 01 Mar, 2022
  • 23 locations
European/International FMD Registry and Initiative (FEIRI)

The main objectives of FEIRI are: (i) To describe the demographic and arterial characteristics of FMD and related diseases at a global scale and according to countries and/or ethnic origin (ii) To evaluate the incidence and predictors of novel FMD lesions and complications (iii) To explore the commonalities and differences …

  • 16 May, 2022
  • 1 location
Performance of White Light, NBI and Iodine Staining Endoscopy in the Diagnosis of Esophageal Lesions

The investigators aim to evaluate the performance of Narrow Band Imaging (NBI) endoscopy in Esophageal Squamous Cell Carcinoma (ESCC) screening, as compared to the currently used White Light Endoscopy (WLE) and Lugol's Iodine Staining Endoscopy (ISE). NBI is a simple, safe and non-invasive technique, which can provide real-time optical staining …

Accepts healthy volunteers
squamous cell carcinoma
  • 18 Feb, 2022
  • 2 locations
The Budesonide in Babies (BiB) Trial (BiB)

compared to surfactant alone, will reduce the incidence of physiologic bronchopulmonary dysplasia (BPD) or death by 36 weeks' post-menstrual age in extremely preterm infants.

  • 25 Apr, 2022
  • 13 locations
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with

gastroesophageal reflux
intestinal metaplasia
Accepts healthy volunteers
  • 10 Oct, 2021
  • 6 locations
Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients

This is a nationwide, multicenter, randomized, prospective, real-world study. The purpose of this study is to evaluate the effect and safety of Yangzheng Compound Mixture in the treatment of sleep disorder in cancer patients with Qi-Yin deficiency syndrome during chemotherapy.

cancer diagnosis
conventional treatment
sleep problem
chemotherapy regimen
  • 17 Mar, 2022
  • 9 locations
A Study of HLX10 in Combination With Carboplatin Plus (+) Pemetrexed With or Without HLX04 Compared With Carboplatin+Pemetrexed in 1L Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

This study involves a two-part design. Part 1 is designed to evaluate the safety and tolerability of the 4 drug (HLX10+HLX04+carboplatin+pemetrexed). Part 2 is a randomized, open-label study, which will evaluate the safety and efficacy of HLX10 in combination with carboplatin+pemetrexed with or without HLX04(biosimilar of avastin) compared with treatment …

administration intravenous
measurable disease
  • 13 May, 2022
  • 1 location
Study of Lorlatinib In People With ALK-positive Non-small Cell Lung Cancer

The purpose of this clinical trial is to learn whether the study medicine (called lorlatinib) is safe and effective for the treatment of non-small cell lung cancer that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene. This study is seeking participants whose lung cancer has progressed after receiving …

administration intravenous
anaplastic lymphoma
chemotherapy regimen
metastatic non-small cell lung cancer
  • 15 Jun, 2022
  • 21 locations