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Found 762 clinical trials
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis (POCA)

patients will require surgical interventions because of fulminant colitis, dysplasia, cancer, or medical refractory diseases. Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the

  • 05 Mar, 2022
umBilical Or Adult Donor Red Blood Cells in Extremely Low Gestational Age Neonates and Retinopathy of Prematurity (BORN)

of fetal hemoglobin (HbF) and severity of retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD), two disabilities that frequently complicate preterm birth. This association is not

  • 12 Dec, 2021
  • 2 locations
Immune Checkpoint Inhibitor In High Risk Oral Premalignant Lesions

size or in grade of dysplasia) may not be enough to assess the potential benefit of an intervention. Modulation of molecular markers may be more precise indicator of oral cancer risk in patients with

  • 27 Jan, 2021
  • 5 locations
Landmark vs. Ultrasound-Assisted Bone Marrow Biopsy Procedure Study (LUMP)

cytopenia, leukemia, lymphoma, myelodysplastic syndrome, or plasma cell dyscrasia. The bone marrow is sampled from the posterior iliac crest, ideally by drilling into the posterior superior iliac spine

  • 02 Jun, 2022
  • 1 location
Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants

The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of ventilation in preterm twins infants with respiratory distress syndrome

  • 25 Feb, 2021
  • 1 location
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach

This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.

  • 08 May, 2021
  • 1 location
Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis

Actinic cheilitis is a condition of the lower lip characterized by grayish-white areas of discoloration and blunting of the demarcation between the cutaneous lip and the mucosa. While many studies have compared treatment options for actinic cheilitis, there is still significant debate over how to best manage this condition. The …

  • 22 Aug, 2021
  • 1 location
A Study of Agreement Between Oxygen Saturation Measured by Two Probes in Infants on the Neonatal Unit

On the neonatal unit in Derby, two types of probes are in routine use: Mindray 520 N and Mindray 521 N. Feedback from parents and staff show that there are concerns that the two probes given very different oxygen saturation readings and, often, do not agree with each other. This …

Accepts healthy volunteers
  • 10 Oct, 2021
  • 1 location
Treatment for Elderly Fit Newly Diagnosed Multiple Myeloma Patients Aged Between 65 and 80 Years

The study is designed as a randomized, controlled, open-label, assessor blind, multicenter superiority trial with three parallel groups, and primary endpoint of immunophenotypic complete responses at 18 months after randomization. Block randomization will be performed with a 1:1:1 allocation ratio. Patients will be randomized up front to 3 arms. Patients …

  • 24 Mar, 2021
  • 89 locations
Fecal Microbiota Transplantation for Pouchitis

This is a randomized double-blind placebo controlled trial involving a single centre (McMaster University) recruiting patients from Hamilton, ON and the surrounding regions, to evaluate whether fecal microbiota transplantation once weekly for six weeks increases the remission rate compared to placebo in patients with active pouchitis.

  • 23 Apr, 2022
  • 1 location