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Found 256 clinical trials
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Deep Brain Stimulation Surgery for Movement Disorders

. Stimulating these areas helps to block the nerve signals that cause abnormal movements. Researchers also want to record the brain function of people with movement disorders during the surgery.

parkinson's disease
dopamine
blood test
intention tremor
dyskinesia
  • 190 views
  • 03 Nov, 2021
  • 1 location
None
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease

without addressing the underlying mechanisms. Patients with PD who demonstrate significant motor fluctuations and dyskinesia are considered for subthalamic nucleus (STN) deep brain stimulation (DBS

depression
dyskinesia
tremor
brain stimulation
motor symptoms
  • 0 views
  • 20 Oct, 2021
  • 3 locations
None
Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?

PLMs, particularly dopamine agonists, limit the impact of these abnormal movements on sleep fragmentation, daytime alertness and quality of life. Underdiagnosed PLMs in SCI patients can lead to

spinal cord disorder
multiple sclerosis
spinal cord
  • 0 views
  • 24 Jul, 2021
  • 1 location
None
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist to Treat Impulse Control Disorders in Parkinson's Disease.

frequently leads to a worsening of motor signs (parkinsonism or dyskinesias due to the concomitant increase of levodopa doses) and non-motor signs with the appearance of a DA withdrawal syndrome (DAWS).

dopamine
pramipexole
depression
impulse control disorder
dyskinesia
  • 2 views
  • 06 Oct, 2021
  • 29 locations
None
Intervention in Chronic Pediatric Patients and Their Families.

This project consists of a psychological intervention in patients and their families with different chronic diseases in order to carry out a comparative study between medical pathologies to know which are the protective or risk variables for the adaptation to the disease.

chronic diseases
chronic disease
  • 0 views
  • 24 Jan, 2021
None
Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease

To study the effects of Botulinum toxin type A (BTXA) in the treatment of foot dystonia-associated pain in Parkinson's disease

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy

This is an exploratory pilot study to identify neural correlates of specific motor signs in Parkinson's disease (PD) and dystonia, using a novel totally implanted neural interface that senses brain activity as well as delivering therapeutic stimulation. Parkinson's disease and isolated dystonia patients will be implanted unilaterally or bilaterally with …

parkinson's disease
antiparkinsonian agents
botulinum toxin
dyskinesia
brain stimulation
  • 92 views
  • 23 Aug, 2021
  • 1 location
None
The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease

Parkinson disease (PD) is considered a multisystemic neurodegenerative disorder, together with the classic motor disability, and a number of non-motor symptoms (NMS).NMS have a significant negative relation with patients' quality of life. In general, both medicinal and nonmedicinal therapies are often advised for PD patients with NMS, but robust evidences …

motor symptoms
parkinsonism
cognitive decline
neurodegenerative disorders
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
A Clinical Trial for the Safety and Effect of MRGuided FUS Subthalamotomy for Medication Refractory Parkinson's Disease

Study design: This is a prospective, open-label, single-center, and sponsor-initiated clinical trial. The clinical trial follows the Clinical Investigation Plan, GCP. Objective: The objective of the clinical trial is to evaluate improving Parkinson's disease motor features by MR-guided focused ultrasound surgery (Patient who has less effectiveness.).

  • 0 views
  • 16 Apr, 2021
  • 1 location
None
Predictive Value of Multimodal MRI in Parkinson's Disease

Deep brain stimulation (DBS) is recognized as the most safe and effective neurosurgical method for the treatment of advanced Parkinson's disease. However, the mechanism of relieving motor and non-motor symptoms of Parkinson's disease has not been fully clarified, and the prognosis is significantly different. This study is based on multimodal …

brain stimulation
motor symptoms
  • 0 views
  • 08 Oct, 2021
  • 1 location