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Found 257 clinical trials
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 20,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD …

chorea
Accepts healthy volunteers
  • 1057 views
  • 11 Nov, 2021
  • 257 locations
None
Is Caffeine an Environmental Modifier in Huntington's Disease?

The aim of the study is to establish if caffeine consumption is associated with the evolution of the disease in premanifest HD.

chorea
caffeine
  • 208 views
  • 25 Jan, 2021
  • 11 locations
None
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease

Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain …

cognitive assessment
chorea
diffusion tensor imaging
htt gene
autosomal dominant
  • 159 views
  • 27 Feb, 2021
  • 5 locations
None
Measuring Cortisol Levels in Persons With Parkinson's (PD)

The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.

movement disorder
parkinson's disease
nervous system disorder
huntington's disease
chorea
  • 124 views
  • 15 Nov, 2021
  • 2 locations
None
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

HDClarity will seek at least 1200 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high …

chorea
Accepts healthy volunteers
  • 669 views
  • 16 Oct, 2021
  • 27 locations
None
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

disease or disorder
huntington's disease
neurodegenerative diseases
parkinson's disease
multiple sclerosis
  • 8 views
  • 07 Oct, 2021
  • 1 location
None
N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T)

This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of Ataxia-Telangiectasia (A-T). There are two phases to this study: the Parent Study, and the Extension Phase. The Parent Study evaluates the safety and efficacy of …

  • 1 views
  • 18 Apr, 2021
  • 5 locations
None
Open-label Long-term Extension Treatment Using Intra-Erythrocyte Dexamethasone Sodium Phosphate in Patients With Ataxia Telangiectasia Who Participated in the IEDAT-02-2015 Study

This is an international (North America, Europe, Africa, Asia and Australia), multi-center, prospective, open-label treatment study, designed to continue to provide the study medication to all patients who completed 12 months of treatment (including those treated with placebo) in the IEDAT-02-2015 trial, completed the study assessments, do not present safety …

  • 8 views
  • 15 Aug, 2021
  • 18 locations
None
Improving Walking Ability in Parkinson Disease

Gait impairments of patients with Parkinson's disease (PD) limit the independence in the daily activities and sensibly increase the risk of falls. New gait analysis methods, based on wearable inertial sensors, have been proposed to track the gait features during treatment and in real-life conditions. Gait training based on auditory …

gait training
rasagiline
  • 5 views
  • 24 Jan, 2021
  • 1 location
None
Nordic Throwing Shoulder Project (NTS - Project)

As a part of the Olympic program and with 150 countries in the international Handball Federation team handball has become a worldwide popular sport. Unfortunately, a large number of different types injuries have been reported among team handball players, and shoulder pain has some of the biggest incidence. In handball …

range of motion
ache
shoulder injury
injuries
  • 3 views
  • 03 Apr, 2021
  • 2 locations