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Found 100 clinical trials
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes (SWEET-BONE)

Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk despite normal to increased bone mass, thus suggesting poor bone quality. This study is aimed at weighing the effect of an exercise intervention program on parameters of bone quality in patients with type 2 diabetes mellitus. Two hundred patients …

body mass index
type 2 diabetes mellitus
  • 0 views
  • 25 Feb, 2022
  • 1 location
Maximal Fat Oxidation and Fuel Use During Exercise

Fat and carbohydrate are the two main energy stores available as fuel during exercise. It is well known that the exercise intensity and feeding status are the major factors determining the type of fuel used during exercise. During prolonged exercise at low to moderate exercise fat is the primary fuel …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Health and Exercise Response in Children With Chronic and Auto-immune Pathologies (HERCCULE)

The aim of the present project is to assess the effects of the chronic diseases and their associated treatments chronic paediatric diseases (CPD), to further understand their impact on physical fitness for public health perspectives. This is an innovative approach in the treatment of chronic paediatric diseases . This project …

fatigue
chronic disease
Accepts healthy volunteers
chronic inflammation
  • 6 views
  • 07 Feb, 2022
  • 1 location
Effect of Dapagliflozin vs Sitagliptin on Liver Fat Accumulation and Body Composition in Patients With Diabetes Mellitus and Liver Transplantation (Dapa-LiT)

Patients with pre-transplantation type 2 diabetes (T2D) and new-onset diabetes post liver transplantation (NODAT) are managed with multiple doses of subcutaneous insulin (MSI) following liver transplantation. As these patients receive oral glucocorticoids (mostly prednisolone) and immunosuppressants, which elevate blood glucose levels, multiple doses of insulin are usually required. After 2-3 …

hypoglycemic agents
sitagliptin
oral hypoglycemic
metformin
body mass index
  • 0 views
  • 24 Mar, 2022
  • 1 location
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called …

Accepts healthy volunteers
alzheimer's disease
apolipoprotein e
  • 5 views
  • 24 Jan, 2022
  • 1 location
Blood Flow Regulation in Individuals With Down Syndrome - Training Study

Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may …

Accepts healthy volunteers
  • 0 views
  • 16 Oct, 2021
  • 1 location
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)

Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up fat to generate heat for maintenance of body temperature …

Accepts healthy volunteers
metabolic syndrome
fats
body mass index
fasting
  • 9 views
  • 26 May, 2022
  • 1 location
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased CVD risk. The primary mechanisms underlying the age-associated increase in SBP is stiffening of …

Accepts healthy volunteers
stiffness
fasting plasma glucose
total cholesterol
caloric restriction
  • 94 views
  • 24 Mar, 2022
  • 1 location
Microvascular Dysfunction in Obesity

Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-oxidase is a major source of oxidative stress within the vasculature, and …

Accepts healthy volunteers
metabolic syndrome
diabetes
  • 0 views
  • 30 Jun, 2022
  • 1 location
Cold, Appetite and Weight Loss in Individuals With Obesity

This study is an 8 week weight loss intervention with 3 randomly assigned groups: DIET, cold exposure (CE), and DIET+CE. The study will be a total of 13 weeks. All participants will undergo a screening session, two experimental sessions at baseline and two experimental sessions after the intervention. There will …

Accepts healthy volunteers
caloric restriction
  • 7 views
  • 12 May, 2022
  • 1 location