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Found 106 clinical trials
Cellular Adaptations to Training in Patients With Type 2 Diabetes

Physical training can improve metabolic health in patients with insulin resistance and/or type 2 diabetes (T2D). The cellular and molecular changes underlying the improvements in metabolic health are multi-factorial and only partly understood, but most likely involve adaptation at a multi-organ level that includes improvements in skeletal muscle glucose uptake …

  • 0 views
  • 10 Jul, 2021
  • 1 location
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease. T2D and heart disease share many common risk factors such as aging, obesity and unhealthy lifestyle. Paradoxically however, while lowering blood LDL, commonly known as "bad cholesterol", …

fatty acids
body mass index
diabetes
fish oil
heart disease
  • 0 views
  • 09 Sep, 2021
  • 1 location
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI

Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date. Romosozumab, a sclerostin antagonist, has potential to increase bone formation (anabolic) and decrease bone resorption (anti-catabolic) in persons with chronic SCI. Conventional anti-resorptive therapy alone would not be …

spinal cord
x-rays
spinal cord disorder
  • 1 views
  • 29 Apr, 2022
  • 2 locations
Improving Blood Pressure and Cardiovascular Risk With Resistance Exercise in African Americans (BPVR)

After the participant meets all inclusion and exclusion criteria, they will be randomized equally to either the Resistance Training group (RT) or Aerobic Training group (AT). Both groups will participate in an 8 week initial control period, followed by 8 weeks of supervised exercise training, followed by 8 weeks of …

stiffness
stress test
urine analysis
body mass index
  • 29 views
  • 24 Feb, 2022
  • 1 location
Timing of Eating Study Among Obese Adults

The randomized, cross-over design study is designed to determine how timing of eating affects weight, adiposity, energy metabolism, and gene expression. Obese participants will be provided isocaloric meals and snacks to be consumed in one of two prescribed eating conditions -- daytime eating and delayed eating.

Accepts healthy volunteers
  • 171 views
  • 01 Feb, 2022
  • 1 location
Health and Exercise Response in Children With Chronic and Auto-immune Pathologies (HERCCULE)

The aim of the present project is to assess the effects of the chronic diseases and their associated treatments chronic paediatric diseases (CPD), to further understand their impact on physical fitness for public health perspectives. This is an innovative approach in the treatment of chronic paediatric diseases . This project …

chronic inflammation
Accepts healthy volunteers
chronic disease
fatigue
  • 6 views
  • 07 Feb, 2022
  • 1 location
Models of Primary Osteoporosis Screening in Male Veterans (MOPS)

Models of Osteoporosis Screening in Male Veterans aims to test 1 distinct care model of primary osteoporosis screening in men within the VA healthcare setting. All care models deliver VA recommended osteoporosis screening and treatment to high-risk Veterans by appropriate Durham VA clinical staff. The MOPS project will evaluate patient, …

diabetes
stroke
hyperparathyroidism
hyperthyroidism
primary osteoporosis
  • 3 views
  • 26 Mar, 2022
  • 2 locations
Multimodality Intervention for Function and Metabolism in SCI

The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury. The trial will test the hypothesis that a Home-Based Multimodality Functional Recovery and Metabolic Health Enhancement Program that addresses …

spinal cord
spinal cord disorder
electrical stimulation
  • 0 views
  • 13 Aug, 2021
  • 1 location
Effects of Microbial Enzyme Supplementation on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Middle-Aged and Older Adults (BIO-3003)

The primary objective of this study is to investigate the acute effects of a microbial multi-enzyme mixture ("BC-006") on postprandial nutrient levels in healthy, middle-aged to older adults during a mixed meal tolerance test. Additionally, the effects of twice daily consumption of BC-006 and placebo for 3 weeks on abdominal …

Accepts healthy volunteers
  • 0 views
  • 22 Mar, 2022
  • 1 location
The Effectiveness and Safety of Tenofovir Alafenamide in the Treatment of Chronic Hepatitis B Patients With Mildly Elevated Alanine Aminotransferase and Significant Liver Injury.

In Taiwan, non-cirrhosis CHB patients with mildly elevated ALT are not candidates for antiviral treatment under Taiwan NIH reimbursement criteria. Disease severity could range from mildly liver injury to cirrhosis in this group of patients. There is a substantial population of patients required antiviral treatment, but not fulfill the criteria …

  • 0 views
  • 28 Jan, 2021
  • 1 location