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Found 106 clinical trials
Skeletal Health and Bone Marrow Composition Among Youth

Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist medications. This has the possibility of impacting bone development as sex steroids are important to bone mass development. In this multi-site study, …

  • 0 views
  • 04 Sep, 2021
  • 1 location
Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults (HT)

The overall objectives are to: Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels. Systematically compare different HIIT regimens to help identify effective "doses" of HIIT that may be optimal for improving metabolic health in obese adults. Assess the ability/willingness of obese subjects to …

insulin
body mass index
insulin resistance
glucose concentration
  • 55 views
  • 27 Apr, 2022
  • 1 location
Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema (Lipedema)

Lipedema is a disorder characterized by massive, bilateral accumulation of fat below the waist and in the legs. Enlargement of the lower extremities is often accompanied by leg pain and accumulation of fluid. Little is known about the functional changes that lead to fat accumulation and pain in women with …

Accepts healthy volunteers
  • 318 views
  • 09 Apr, 2022
  • 1 location
Incorporating Nutrition, Vests, Education, and Strength Training in Bone Health (INVEST in Bone Health) (INVEST)

The main goal of the proposed study is to compare the effects of weight loss (WL) alone with WL plus weighted vest use or WL plus resistance exercise training (RT) on indicators of bone health and subsequent fracture risk.

  • 124 views
  • 13 Mar, 2022
  • 1 location
Healthy Body Healthy Bones After Bariatric Surgery Trial

One in three adults in the United States suffers from obesity. Bariatric surgery is an increasingly utilized and effective treatment for obesity and obesity-related comorbidities, however, the massive weight loss associated with bariatric surgery adversely affects bone leads to an increased risk of fracture. Bisphosphonate medications, such as zoledronic acid, …

zoledronic acid
osteoporosis
Accepts healthy volunteers
bisphosphonate
  • 76 views
  • 19 Nov, 2021
  • 1 location
Isolated and Combined Effect of a Low Carbohydrate Diet and Exercise in Hypoxia in Patients With Type 2 Diabetes

The purpose of this study is to determine the effects of isolated chronic exercise in hypoxia and combined exercise in hypoxia with a low carbohydrate diet on hypoxia-induced transcription factor (HIF1-α); glycaemic control and cardiovascular risk factors in patients with type 2 diabetes.

  • 0 views
  • 25 May, 2022
Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents

The primary aim of this proposal is to determine the effects of soluble corn fiber (SCF) supplementation for 1 year on bone metabolism in growing adolescents compared to controls. For the proposed study, a randomized double-blinded placebo controlled clinical trial will be conducted in 236 healthy adolescents aged 10-13 years, …

calcium
bone mineral density
body mass index
Accepts healthy volunteers
  • 34 views
  • 30 May, 2022
  • 1 location
Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid

Osteogenesis imperfecta (OI) is an inherited skeletal disorder characterised by increased risk of fragility fractures. Bisphosphonates are frequently prescribed for adult patients with OI with the aim of preventing fractures but the evidence base for efficacy is poor. Recent evidence suggests that the bone anabolic agent teriparatide (TPTD) increases bone …

care adult
bisphosphonate
zoledronic acid
parathyroid hormone
bone mineral density
  • 156 views
  • 22 Jan, 2021
  • 25 locations
Aerobic vs Resistance Exercise in Post-menopausal Women With Type 1 Diabetes

Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third …

menstrual period
continuous glucose monitoring
blood sugar
diabetes
oophorectomy
  • 0 views
  • 22 Mar, 2022
  • 1 location
Physical Fitness/Training and Inflammatory Immune Responses in Patients With End-stage Renal Disease

The end-stage renal disease (ESRD) leading two causes of death are cardiovascular diseases and sepsis. Exercise improves low physical fitness, available research concerning its effect on the pro-/anti-inflammatory immune response is scarce. In the current proposal, physical fitness is classified into cardiopulmonary fitness and muscle fitness. Muscle fitness is further …

  • 0 views
  • 11 Jul, 2021
  • 1 location