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Found 90 clinical trials
Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants are randomized to endurance exercise (EE) training, resistance exercise …

Accepts healthy volunteers
  • 17 Feb, 2022
  • 9 locations
The Healthy Diet and Lifestyle Study II ((HDLS2))

question is whether a diet plan combining IER and the MED dietary pattern will be superior to MED/DER in reducing abdominal MRI-measured visceral and liver fat and dual-energy X-ray absorptiometry (DXA

Accepts healthy volunteers
  • 02 May, 2022
  • 1 location
Evaluation of a Nurse-led Program for the Prevention of Complications of Long-term Corticosteroid Therapy (COCORTICO)

Long term corticosteroid therapy concerns 0.5 to 1% of the population and about 2.5% of elderly subjects. It is currently used as a cornerstone therapy in a wide variety of clinical contexts. The central problematic of prolonged corticosteroid therapy is the burden of adverse events associated with its long term …

  • 04 Oct, 2022
  • 1 location
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol (MoTrPAC)

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, studies will be conducted in adults and separately in children and adolescents. The UC Irvine MoTrPAC Pediatric Clinical Center oversees two interrelated …

  • 08 Jul, 2022
  • 1 location
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes (ALLEVIATE)

Open, Single arm intervention, feasibility study

  • 09 Jun, 2022
  • 1 location
Muscle Stimulation for Physical Function During Stem Cell Transplant

Some blood, bone marrow, and lymphatic (hematologic) cancers such as Hodgkin/Non-Hodgkin lymphomas, chronic lymphocytic leukemia, and multiple myeloma, are over-represented in Veterans due to exposures including Agent Orange and an increased percentage of patients of African American ethnicity. Hematologic transplantation (HCT) is a common treatment for these cancers, but often …

  • 14 May, 2022
  • 1 location
Benefits of Ketogenic Diet in Patients With Heart Failure With Preserved Ejection Fraction: A Pilot Study

This study is being done to evaluate the effects of a low carbohydrate ketogenic diet on exercise tolerance in patients with Heart Failure with Preserved Ejection Fraction (HFpEF), also known as Diastolic Heart Failure (DHF).

body mass index
medical therapy
diastolic heart failure
  • 23 Oct, 2022
  • 1 location
Combining a Mediterranean Diet With Physical Activity to Address Cardiometabolic Risk

There is little doubt scientifically that healthy eating, such as adhering to the Mediterranean diet (MedDiet) principles, is key for the prevention of cardiovascular disease (CVD). There is also convincing evidence for a strong inverse relationship between moderate intensity physical activity (PA) and mortality. Surprisingly, no study has yet formally …

  • 04 Oct, 2022
  • 1 location
Sex Differences in Metabolism Following a High-fat Meal (HFM)

Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2 diabetes. Women tend to be better protected against the development of …

Accepts healthy volunteers
  • 07 Oct, 2022
  • 1 location
Exercise and Nutrition for Healthy AgeiNg (ENHANce)

The aim of this randomized placebo-controlled 5-arm clinical trial is to evaluate the effect of combined anabolic interventions compared to single or placebo interventions on physical performance in community-dwelling (pre)sarcopenic elderly ( 65 years) and to determine the underlying mechanisms of action. Important secondary outcome measures are muscle mass, muscle …

fatty acids
heart failure
omega-3 fatty acids
protein supplement
nutritional supplementation
  • 13 Feb, 2022
  • 1 location