Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 6 clinical trials
Dornase Alfa and Urokinase for Kids With Pleural Empyema

The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with

  • 10 views
  • 07 Nov, 2020
  • 2 locations
Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy

therapies can be safely stopped. The SIMPLIFY study is being done to test whether or not it is safe to stop taking inhaled hypertonic saline or Pulmozyme (dornase alfa) in those people that are also taking

pulmonary function test
fibrosis
dornase alfa
forced expiratory volume
ivacaftor
  • 55 views
  • 26 Jan, 2021
  • 74 locations
Nebulised Dornase Alfa for Treatment of COVID-19

An open-label, randomised, Best-Available-Care (BAC) and historic-controlled trial of nebulised dornase alfa [2.5 mg BID] for 7 days in participants with COVID-19 who are admitted to hospital

d-dimer
PCR test
oximetry
SARS
coronavirus infection
  • 0 views
  • 26 Jan, 2021
  • 1 location
Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

The purpose of this study is to evaluate the efficacy and safety of intrapleural dornase alfa and tPA administered to patients with clinical failure of small-bore chest tube with persistent

  • 158 views
  • 19 Feb, 2021
  • 1 location
Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)

This study plans to learn more about the effects of Dornase Alfa in COVID19 (coronavirus disease of 2019) patients, the medical condition caused by the Severe Acute Respiratory Syndrome

mechanical ventilation
coronavirus
respiratory distress
assisted breathing
fibrosis
  • 7 views
  • 01 May, 2021
  • 1 location
Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma

respiratory distress syndrome (ARDS). Considering that many DAMPs and all NETs are made of nucleic acids, we hypothesize that dornase alfa, a commercially available recombinant desoxyribonuclease

mechanical ventilation
pulmonary contusion
ventilator-induced lung injury
assisted breathing
proteolytic enzymes
  • 0 views
  • 11 Sep, 2021
  • 1 location