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Found 170 clinical trials
Dopaminergic Dysfunction in Late-Life Depression (D3)

. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dopamine transporters. Although brain changes associated with depression and aging converge on dopamine

  • 0 views
  • 12 Mar, 2022
  • 1 location
Do Antipsychotic Agents Induce Supersensitivity in Humans: A Combined PET/MRI Study in Patients With Schizophrenia

The aim of the present study is to detect changes in the dopamine system in the brain of patients with schizophrenia, especially when pretreated with antipsychotic medication. Here, the

  • 0 views
  • 04 Mar, 2021
  • 1 location
Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment

This project aims to develop electroretinogram as a new putative marker for dopamine release, and as a predictor of treatment response among patients seeking treatment for smoking cessation

electroretinogram
substance use
behavior therapy
Accepts healthy volunteers
a 12
  • 340 views
  • 06 May, 2022
  • 1 location
Dopaminergic restauratIon by intraVEntriculaire Administration (DIVE)

over study (2 periods of 1 month) to demonstrate that cerebroventricular administration of A-dopamine (dopamine prepared in anaerobia to avoid dopamine oxidation) affords a better control of motor

motor symptoms
dopa
dopamine
levodopa
dyskinesia
  • 0 views
  • 25 Jan, 2022
  • 1 location
Psychobiological Mechanisms Underlying Chronic Pain

neurotransmitter dopamine. In line with this observation, impaired dopamine functioning has been described in chronic pain. Importantly, dopamine acts also as a neuromodulator, regulating functional connectivity

depression
Accepts healthy volunteers
fibromyalgia
anxiety
sham treatment
  • 0 views
  • 12 Mar, 2022
  • 1 location
Study on Therapy of Non-invasive Prolactinoma (TNAPA)

the study aim to investigate the endocrine remission rate of non-invasive prolactinoma between transsphenoidal surgery treatment and Dopamine agonist treatment.

  • 0 views
  • 24 Feb, 2022
Raclopride-PET/MRT

dopaminergic system. Therefore, characteristics of cerebral dopamine receptors before and after administration of nasal insulin vs. placebo shall be analyzed in a randomized way. Moreover, the investigators

insulin sensitivity
insulin resistance
Accepts healthy volunteers
  • 6 views
  • 12 Feb, 2022
  • 1 location
Social Decision Making in Parkinson's Disease

Impulsive and compulsive behaviors occur in up to 46% of Parkinson's Disease (PD) patients taking dopamine agonist (DAA) medications. While these abnormal social behaviors have been studied in

neurodegenerative disorders
pramipexole
carbidopa
dopamine agonists
dopamine
  • 1 views
  • 18 May, 2022
  • 1 location
Changes in Glutamatergic Neurotransmission of Severe TBI Patients

required for consistent goal-directed behavior and arousal regulation. Since dopamine levels are one of the primary controllers of the level of synaptic background activity within these forebrain

amantadine
dopamine
Accepts healthy volunteers
  • 62 views
  • 10 Oct, 2021
Effects of 5HTP and LDOPA on CNS Excitability After SCI

This study will examine whether supplementation with the serotonin and dopamine precursors, 5HTP and L-DOPA can alter central nervous system excitability and improve motor function after

nervous
injuries
spinal cord
spinal cord disorder
spasticity
  • 42 views
  • 11 Feb, 2022
  • 1 location