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Found 171 clinical trials
Effects of MDMA-like Substances in Healthy Subjects

The serotonin (5-HT) and oxytocin releaser and so-called "empathogen" 3,4-methylenedioxymethamphetamine (MDMA) acutely produces positive feelings, empathy, and trust. MDMA is used recreationally (ecstasy), as research tool to study 5-HT and oxytocin function, and is investigated for MDMA-assisted psychotherapy. MDMA is metabolized in part (10%) to the psychoactive metabolite 3,4-methylenedioxyamphetamine (MDA) …

Accepts healthy volunteers
  • 50 views
  • 05 Jan, 2022
  • 1 location
Nicotinic Receptor Genetic Variation and Alcohol Reward

Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …

Accepts healthy volunteers
  • 59 views
  • 06 Jul, 2022
  • 1 location
Tianeptine for Treatment Resistant Depression

The study will be conducted in parallel at two sites: the Clinic for Aging, Anxiety and Mood Disorders (CAAM) at Columbia University/New York State Psychiatric Institute (CU/NYSPI) and the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM). The following procedures will be approved …

antidepressants
depressive disorder
mirtazapine
snri
bupropion
  • 37 views
  • 21 Apr, 2022
MotIoN aDaptive Deep Brain Stimulation for MSA (MINDS)

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), …

parkinsonism
parkinson's disease
  • 0 views
  • 25 Mar, 2022
  • 1 location
PRolaCT - Three Prolactinoma RCTs

(>2 years) period of pretreatment with a dopamine agonist is superior to standard care for several outcome parameters. The main objectives are to investigate this for quality of life and remission

  • 0 views
  • 24 Jan, 2021
  • 3 locations
COG-PSYCHO : Social Cognition and Psychotic Characteristics: Genetic and Phenomic Approach

dopamine pathways may be involved SC performance. Our endophenotype approach aimed to demonstrate that SC deficits are more severe in schizophrenia and BD or depression with psychotic symptoms (PBP) and

  • 18 views
  • 24 Jun, 2021
  • 1 location
CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease) (CHIEF PD)

population ages, the number of people living with Parkinson's disease and the occurrence of complications will increase. The loss of the chemical dopamine in the brain causes walking in Parkinson's to become

dopamine
  • 37 views
  • 23 Feb, 2022
  • 27 locations
EA for PAAS: A pRCT

the biology underlying amphetamine withdrawal syndrome is not fully understood, amphetamine has been shown to produce long-lasting reductions in neuronal expression of dopamine neuronal markers. Abuse

addiction
anxiety
stimulant
psychostimulant
psychiatric symptoms
  • 9 views
  • 15 Jun, 2021
  • 1 location
Pragmatic Trial of Obsessive-compulsive Disorder

This study includes a sequenced clinical trial in order to assess the efficacy of several switching or augment strategies when initial treatment is ineffectiveand to provide strong evidence for clinical practice and international guidelines for Obsessive-Compulsive Disorder treatments.

sertraline
memantine
fluvoxamine
psychotherapy
treatment regimen
  • 5 views
  • 15 Jul, 2021
  • 1 location
Diagnosis of Pheochromocytoma

The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas. These tumors, which usually arise from the adrenal glands, are often difficult to detect with current methods. Pheochromocytomas release chemicals called catecholamines, causing high blood pressure. Undetected, the tumors can lead to severe …

computed tomography
metastatic disease
dopa
MRI
18f-fdg
  • 20 views
  • 05 Jul, 2022
  • 1 location