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Found 170 clinical trials
Does Caffeine Facilitate Human Reward Learning Behaviors? (ADoRe)

affecting the brain and nervous system. By such effects, caffeine enhances reward signals - dopamine - in human brains. In this research study, we will find out whether taking caffeine acutely or daily can

Accepts healthy volunteers
  • 0 views
  • 03 Jun, 2022
Bromocriptine in the Treatment of Peripartum Cardiomyopathy (BRO-HF)

anti-angiogenic effects that may promote PPCM. Bromocriptine, a central dopamine agonist known to decrease prolactin levels, might thwart its deleterious effects in women suffering from PPCM. Following

  • 37 views
  • 25 Feb, 2022
  • 1 location
Developing an EEG Paradigm to Study Prediction Error in Anorexia Nervosa

altered reward processing in AN including in studies using the dopamine associated prediction error (PE) model. The brain PE response is elicited during unexpected receipt or omission of reward stimuli

Accepts healthy volunteers
  • 0 views
  • 25 Feb, 2021
  • 1 location
The Effect of Guanfacine on Delirium in Critically Ill Patients

cost, increased ventilator days, and long-term cognitive disability. Various pharmacologic agents including dopamine antagonists, acetylcholinesterase inhibitors, melatonin, antipsychotics, alpha-2

  • 9 views
  • 26 Nov, 2021
  • 1 location
The Effect of iTBS on the Inhibition Control Function of BN

function of the prefrontal lobe-striatum neural circuits dopamine system. By the objective markers of peripheral, brain imaging and behavior of BN, to provide new targets and ideas for the treatment of BN

Accepts healthy volunteers
  • 7 views
  • 21 Mar, 2022
  • 1 location
Apomorphine in Severe Brain-injured Patients (APODoC)

challenging because of scarce and inefficient therapeutical options. Among pharmacological treatments, apomorphine, a potent direct dopamine agonist, has exhibited promising behavioral effects, but its true

  • 0 views
  • 22 Mar, 2022
  • 1 location
TAME-PD - Physical Therapy, Atomoxetine and, Methylphenidate, to Enhance Gait and Balance in Parkinson's Disease (TAME-PD)

Gait and balance problems are a significant source of disability in patients with Parkinson disease. Physical therapy remains one of the main treatments. On the other hand some medications, such as methyphenidate and atomoxetine, have been tried with promising results. The outcomes in gait and balance in Parkinson disease after …

medication regimen
  • 18 views
  • 23 Mar, 2022
  • 1 location
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant

The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of Mavoglurant and placebo.

Accepts healthy volunteers
  • 0 views
  • 19 Jun, 2022
  • 1 location
5HTP Regulation Of Asthma In Children

The purpose of this study is to learn more about if taking a supplement called 5-hydroxytryptophan (5HTP) can improve breathing and anxiety symptoms related to asthma. To help learn more subjects will either be assigned to a group that is taking the supplement (5HTP) or a group that is taking …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Effects of MDMA-like Substances in Healthy Subjects

The serotonin (5-HT) and oxytocin releaser and so-called "empathogen" 3,4-methylenedioxymethamphetamine (MDMA) acutely produces positive feelings, empathy, and trust. MDMA is used recreationally (ecstasy), as research tool to study 5-HT and oxytocin function, and is investigated for MDMA-assisted psychotherapy. MDMA is metabolized in part (10%) to the psychoactive metabolite 3,4-methylenedioxyamphetamine (MDA) …

Accepts healthy volunteers
  • 50 views
  • 05 Jan, 2022
  • 1 location