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Found 167 clinical trials
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study

Psychosis is a heterogeneous disorder and present treatment only works for a limited number of patients. In order to identify new therapeutic targets, this study will longitudinally characterize the underlying pathologies in those with poor treatment response using complimentary brain imaging modalities.

risperidone
aripiprazole
antipsychotics
  • 105 views
  • 26 Feb, 2022
  • 1 location
Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of -synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in patients with idiopathic REM Sleep Behavior Disorder (iRBD) and healthy controls.

neurodegenerative disorders
narcolepsy
synucleinopathy
neurodegeneration
Accepts healthy volunteers
  • 309 views
  • 14 Feb, 2022
  • 1 location
Clinical Laboratory Evaluation of Chronic Autonomic Failure

Background The autonomic nervous system controls automatic body functions. Researchers want to improve the tests used to diagnose autonomic failure. Orthostatic hypertension is a drop in blood pressure when a person stands up. Researchers want to focus on this sign of autonomic failure. Objective To improve testing for conditions that …

cardiac symptoms
diabetes
sympathectomies
pure autonomic failure
orthostatic hypotension
  • 222 views
  • 27 Jul, 2022
  • 1 location
Gaucherite - A Study to Stratify Gaucher Disease

The purpose of this research is to review data already collected and to collect new data from adults and children in England with Gaucher Disease to determine clinical factors which predict severity and response to therapy of Gaucher disease especially in the areas of bone, cancer and brain conditions.

enzyme therapy
cancer
  • 117 views
  • 28 Jul, 2021
  • 8 locations
Progression Follow up of the First-degree Relatives of Patients With REM Sleep Behavior Disorder

REM sleep behavior disorder is a novel and distinct parasomnia characterized by recurrent dream enactment behaviors (DEBs) and polysomnographic features of REM sleep without atonia (RSWA), with typical onset age at early 60's. Idiopathic RBD (iRBD) has been suggested as a most specific precursor of α-synucleinopathy-related neurodegeneration (e.g. Parkinson's disease …

Accepts healthy volunteers
parkinsonism
constipation
movement disorder
  • 0 views
  • 03 Jun, 2022
  • 1 location
The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis (Smoke-MS)

Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life. Cigarette smoke has been found to be associated with sleep disturbances in healthy adult smokers, but this relationship …

  • 0 views
  • 21 Apr, 2022
  • 1 location
BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies

Migraine is the 2nd most disabling neurological disease. It affects 14.7% of the population (children and adults) of whom 80% are female. In the European Union, the total annual cost of migraine is of 111 billion euros. If not adequately treated, migraine can evolve into the more severe chronic form …

  • 0 views
  • 05 May, 2021
  • 3 locations