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Found 165 clinical trials
The GBA Multimodal Study in Parkinson's Disease

neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the

positron emission tomography
parkinson's disease
dopamine
acetylcholine
gba gene
  • 0 views
  • 25 Jan, 2022
  • 3 locations
Imaging Biomarkers in Parkinson s Disease

Background Parkinson s disease (PD) causes slow movement, stiffness, and tremor. It results from the loss of a brain chemical called dopamine. PD gets worse over

cognitive decline
dopamine
tremor
Accepts healthy volunteers
  • 117 views
  • 22 Jul, 2022
  • 1 location
Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function

Accepts healthy volunteers
anorexia
bulimia nervosa
dopamine
purging
  • 0 views
  • 17 Jun, 2022
  • 1 location
Unravelling the Alteration of Brain Structure and Function in Parkinson´s Disease With Ultra-high Field MRI (7TPD)

impairment. The motor symptoms can in some degree be attributed to degeneration of the substantia nigra (SN) and a deficiency of dopamine (DA) availability, and DA replacement therapy can partially alleviate

bradykinesia
cognitive impairment
depression
motor symptoms
dopamine
  • 41 views
  • 30 May, 2022
  • 2 locations
Change in Cognitive Function in Stimulant Users

because it releases three times more dopamine than cocaine and the effects can last from eight to twelve hours, compared to two hours for cocaine. On top of its extreme effects, methamphetamine is

  • 0 views
  • 29 Nov, 2021
  • 1 location
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain

This pilot research study is being performed to learn more about pain and look at how pain changes brain chemistry and function. The research team would like to learn new information to better control chronic pain after surgery. This information collected in this research will be used to plan possible …

  • 0 views
  • 02 Sep, 2021
  • 1 location
Real-life Assessment of Abilify Maintena + Rexult in Schizophrenia (MainRexult)

MainRexult study aims to carefully evaluate a cohort of patients with schizophrenia and related disorder prescribed with the combination therapy with Abilify Maintena and Rexulti on its efficacy and tolerability in a real-life clinical setting.

  • 0 views
  • 09 Apr, 2022
  • 1 location
Neural Correlates of Impulsivity in Idiopathic REM Sleep Behavior Disorder

This study aims to investigate the neural correlates (structural changes, functional connectivity, and structural connectivity of brain structures in prefrontal cortex and basal ganglia) of impulsivity by measuring structures and the blood-oxygen-level-dependent signal of brain in response to impulsive tasks and task-free using functional Magnetic Resonance Image method among healthy …

Accepts healthy volunteers
  • 0 views
  • 11 May, 2022
  • 1 location
Factors and Outcomes Associated With Postpartum Cabergoline Use

Cabergoline is frequently being requested by many postpartum women with a live newborn to suppress lactation. The aim of the study is to investigate which women desire such an intervention, and what side effects they are experiencing.

Accepts healthy volunteers
  • 30 views
  • 09 Feb, 2022
  • 1 location
Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of -synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in patients with idiopathic REM Sleep Behavior Disorder (iRBD) and healthy controls.

narcolepsy
Accepts healthy volunteers
neurodegenerative disorders
neurodegeneration
synucleinopathy
  • 309 views
  • 14 Feb, 2022
  • 1 location