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Found 167 clinical trials
PET Scanning in Parkinson s Disease

This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and

movement disorder
neurologic examination
dopamine
tremor
dopa
  • 47 views
  • 29 Jul, 2022
  • 1 location
Search for New Methods to Detect Acute Renal Failure

The purpose of this study is to find substances in the blood and urine that indicate that a person has kidney damage. It will identify proteins found only in patients with acute kidney failure but not in normal healthy people or in patients with volume depletion. Adults and children who …

antibiotics
renal failure
acute renal failure
chronic renal failure
Accepts healthy volunteers
  • 79 views
  • 25 Jul, 2022
  • 1 location
Inpatient Evaluation of Adults With Schizophrenia

The purpose of this study is to understand the biologic basis of schizophrenia and to determine which symptoms are related to the illness itself and which are related to medications used to treat the illness. Schizophrenia and related psychoses are chronic brain disorders whose prognosis is often poor and whose …

psychosis
psychotropic drugs
schizophrenia
functional magnetic resonance imaging
schizoaffective disorder
  • 341 views
  • 29 Jul, 2022
  • 1 location
Phenotype/Genotype Correlations in Movement Disorders

The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients …

  • 45 views
  • 29 Jul, 2022
  • 1 location
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)

Progressive Supranuclear Palsy (PSP), Cortico-Basal Degeneration (CBD) and Multiple System Atrophy (MSA) are degenerative brain conditions for which there are currently no curative treatments. To aid the development of new treatment trials, there is a pressing need to develop better methods for diagnosing these conditions early, and to track disease …

atrophy
progressive supranuclear palsy
mri brain
brain mri
parkinsonism
  • 505 views
  • 25 Jan, 2022
  • 1 location
Simple Observational Critical Care Studies (SOCCS)

Each year approximately 3000 patients are admitted to the intensive care unit (ICU) in the University Medical Center Groningen (UMCG). In-hospital mortality of patients with emergency admission approaches 25%. Predicting outcome in the first hours after ICU admission, however, remains a challenge. An vast amount of scoring systems has been …

acute renal failure
critical illness
organ failure
  • 38 views
  • 04 Mar, 2022
  • 1 location
Dopamine and Motor Learning in Cerebral Palsy

Background Cerebral palsy (CP) is the most common childhood motor disability. The neurotransmitter dopamine (DA) is important in cognition and emotions/behavior

MRI
Accepts healthy volunteers
  • 33 views
  • 26 Jul, 2022
  • 1 location
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

Background Some illnesses, such as schizophrenia, have effects on brain cells called dopamine receptors, which are required for normal brain function. People with

delusions
schizophrenia
dopamine
Accepts healthy volunteers
hallucinations
  • 208 views
  • 22 Jul, 2022
  • 1 location
Vestibulopathy as a Cause of Imbalance in Parkinson

Balance problems and falls are common in people with Parkinson's disease but respond poorly to dopamine stimulating medications suggesting other causes. The main goal of this study is to assess

dementia
dopamine
  • 0 views
  • 17 Jun, 2022
  • 1 location
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI

particular discussion of dysfunction of tonic/phasic dopamine release or dopaminergic hyperinnervation. Moreover, given the complex interaction of different neurotransmitters, especially in the basal ganglia

Accepts healthy volunteers
  • 0 views
  • 15 Mar, 2022