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Found 167 clinical trials
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A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 626 views
  • 08 Nov, 2020
  • 1 location
Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa

suggested altered reward processing in AN. The neurotransmitter dopamine has a central role in the reward circuitry to drive food approach, and the dynamic interplay between dopamine receptor response and

  • 0 views
  • 12 Sep, 2021
  • 1 location
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement (CRC289A07)

studies show reduced reward processing in clinical and subclinical depression, presumably due to abnormalities in the dopamine (DA) system. Here, the investigators will test whether expectation-induced

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

The purpose of this study is to examine the effect of dopamine infusion and dopamine-2 receptor blockade on pulmonary capillary blood volume, diffusion, and the hemodynamic variables of

Accepts healthy volunteers
  • 35 views
  • 26 Apr, 2022
  • 1 location
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall

  • 24 views
  • 25 Jul, 2022
  • 4 locations
[C-11]NPA PET-amphetamine in Cocaine Use Disorders

This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders

  • 0 views
  • 08 Jul, 2022
  • 1 location
Contribution of L-Tyrosine to Human Decision Making in Stressful Situations (TYRO-STRESS)

L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine administration can increase brain dopamine levels and therefore several studies have explored whether tyrosine

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
Exercise in Methamphetamine Use Disorder Upregulation and Neural Function

The purpose of this research study is to determine the effects of an exercise intervention and health-education program on brain dopamine receptors and on cognitive functions that have been

  • 20 views
  • 25 May, 2022
  • 1 location
Does Caffeine Facilitate Human Reward Learning Behaviors? (ADoRe)

affecting the brain and nervous system. By such effects, caffeine enhances reward signals - dopamine - in human brains. In this research study, we will find out whether taking caffeine acutely or daily can

Accepts healthy volunteers
  • 0 views
  • 03 Jun, 2022
Bromocriptine in the Treatment of Peripartum Cardiomyopathy (BRO-HF)

anti-angiogenic effects that may promote PPCM. Bromocriptine, a central dopamine agonist known to decrease prolactin levels, might thwart its deleterious effects in women suffering from PPCM. Following

  • 37 views
  • 25 Feb, 2022
  • 1 location