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Found 8 clinical trials
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration

Addiction to methamphetamine (MA) is a serious health problem in the United States. Right now, there are no medically approved treatments for MA dependence. More research is needed to understand how MA affects the brain and to eventually develop medical interventions for MA addiction. The purpose of the study is …

  • 0 views
  • 12 Mar, 2021
  • 2 locations
Role of Dopamine Transporter in Glucose Control

Healthy subjects will be enrolled in this study. Each subject will be scanned twice with F18-FP-CIT PET which is commercially available. F18-FP-CIT reflects dopamine transporter availability of

  • 69 views
  • 24 Jan, 2021
  • 1 location
Brexpiprazole in Alcohol Use Disorder

, aripiprazole, were influenced by genetic variation in the gene encoding the dopamine transporter (DAT1). This study will evaluate the effects of two doses of BREX, relative to placebo, among non-treatment

scid
functional magnetic resonance imaging
psychiatric disorder
drug abuse
  • 114 views
  • 22 Jul, 2021
  • 1 location
Terazosin Effect on Cardiac Changes in Early Parkinson's Disease

scintigraphy (MIBG) and dopamine transporter (DAT) single photon emission computerized tomography (SPECT) respectively. The combined presence of certain symptoms and the use of these imaging techniques are

  • 0 views
  • 26 Jan, 2021
  • 1 location
Innovative Biomarkers in de Novo Parkinson's Disease

This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical phase.

tremor
bradykinesia
movement disorder
muscle rigidity
resting tremor
  • 2 views
  • 26 Mar, 2021
  • 1 location
Natural History and Disease Progression Biomarkers of Multiple System Atrophy

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease characterised by a variable combination of parkinsonism, cerebellar impairment and autonomic dysfunction. The neuropathological hallmark is the accumulation of alpha-synuclein in oligodendrocytes. While some symptomatic treatments exist, neuroprotective treatments for MSA remain an urgent, unmet need. Moreover, at present …

dysautonomia
orthostatic hypotension
autonomic disorder
alpha-synuclein
SPECT Scan
  • 22 views
  • 12 Feb, 2021
  • 10 locations
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

The study team will determine the association between d,l-methylphenidate (MPH) therapeutic outcomes in ADHD patients and genetic variants of CES1 and reveal key associations between CES1 genotypes and the PK and PD of MPH.

  • 0 views
  • 13 Mar, 2021
  • 4 locations
Multimodal Neurobiological Approaches to Explore the Gene-Environment Interactions in ADHD

Previous studies have demonstrated significant associations of attention-deficit hyperactivity disorder (ADHD) with monoamine transporter genes, including dopamine transporter gene (DAT1

  • 0 views
  • 25 Jan, 2021
  • 2 locations