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Found 13 clinical trials
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A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 558 views
  • 08 Nov, 2020
  • 1 location
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss

This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement. Cabergoline is a medication approved for the symptomatic treatment of pituitary adenomas that result in a hyperprolactinemic state (a brain tumor that results in milk leakage). The benefit …

  • 0 views
  • 01 Mar, 2021
  • 1 location
The Effect of Magnesium Citrate Supplementation in Restless Legs Syndrome (RLS)

, safer, biologically plausible alternative to dopamine agonists and 2 calcium-channel ligands.

dopamine agonists
dopamine
magnesium citrate
restlessness
calcium
  • 69 views
  • 22 Jun, 2021
  • 1 location
Social Decision Making in Parkinson's Disease

other neurodegenerative disorders, the true incidence of social problems, and the relationship to dopamine therapy, in PD patients remains unknown. This study is aiming to determine if dopamine agonists

levodopa
neurodegenerative disorders
pramipexole
dopamine
carbidopa
  • 0 views
  • 25 Jan, 2021
  • 1 location
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas

-producing adenomas, there is no established pharmacological treatment for NFPAs. However, there are a few non-randomized studies suggesting that treatment with dopamine agonists may slow growth, and also

non-functioning pituitary adenoma
hypopituitarism
cabergoline
adenoma
pituitary adenoma
  • 47 views
  • 28 Jan, 2021
  • 3 locations
Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?

PLMs, particularly dopamine agonists, limit the impact of these abnormal movements on sleep fragmentation, daytime alertness and quality of life. Underdiagnosed PLMs in SCI patients can lead to

spinal cord
spinal cord disorder
multiple sclerosis
  • 0 views
  • 24 Jul, 2021
  • 1 location
Bromocriptine for Patients With Schizophrenia and Impaired Glucose Tolerance

/psychoses, 4) pregnancy, or 5) a diagnosis of diabetes. Subjects on other dopamine agonists or on medications that may interact with bromocriptine and those taking corticosteroids or other medications that

schizophrenia 2
insulin resistance
diabetes
body mass index
dopamine
  • 0 views
  • 14 May, 2021
  • 1 location
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist to Treat Impulse Control Disorders in Parkinson's Disease.

There is no consensus on the treatment of Impulse Control Disorder (ICD) in Parkinson Disease (PD) though it is recommended to reduce the dosage of dopamine agonists (DA). Reduction of DA

pramipexole
antidepressants
amantadine
hallucinations
levodopa
  • 1 views
  • 13 May, 2021
  • 29 locations
Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia

The investigators aim to determine the effect of suvorexant on actigraphically-derived total sleep time in patients with effectively treated restless legs syndrome with persistent insomnia in a two-arm, double-blind, randomized placebo-controlled crossover 2.5-month trial.

chronic insomnia
restless legs syndrome
insomnia
wake after sleep onset
suvorexant
  • 0 views
  • 08 Jul, 2021
  • 1 location
Dopamine Effect on Inhibitory Control

The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications. A key confounding factor of many previous studies is that they did not take the disease duration in consideration. In fact, in moderate-to-advanced stages of …

  • 0 views
  • 05 Feb, 2021
  • 1 location