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Found 12 clinical trials
Featured trial
A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 629 views
  • 08 Nov, 2020
  • 1 location
MotIoN aDaptive Deep Brain Stimulation for MSA (MINDS)

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), …

parkinson's disease
parkinsonism
  • 0 views
  • 25 Mar, 2022
  • 1 location
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas

-producing adenomas, there is no established pharmacological treatment for NFPAs. However, there are a few non-randomized studies suggesting that treatment with dopamine agonists may slow growth, and also

pituitary disorders
dopamine agonists
adenoma
prolactin
cabergoline
  • 65 views
  • 12 Sep, 2021
  • 3 locations
Social Decision Making in Parkinson's Disease

other neurodegenerative disorders, the true incidence of social problems, and the relationship to dopamine therapy, in PD patients remains unknown. This study is aiming to determine if dopamine agonists

carbidopa/levodopa
neurodegenerative disorders
dopamine agonists
levodopa
pramipexole
  • 1 views
  • 18 May, 2022
  • 1 location
Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?

PLMs, particularly dopamine agonists, limit the impact of these abnormal movements on sleep fragmentation, daytime alertness and quality of life. Underdiagnosed PLMs in SCI patients can lead to

spinal cord disorder
spinal cord
multiple sclerosis
  • 0 views
  • 24 Jul, 2021
  • 1 location
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. (PIMPARK)

There is no consensus on the treatment of Impulse Control Disorder (ICD) in Parkinson Disease (PD) though it is recommended to reduce the dosage of dopamine agonists (DA). Reduction of DA

depression
dopamine agonists
anticholinergic agents
pramipexole
dopamine
  • 2 views
  • 25 Mar, 2022
  • 3 locations
Bromocriptine for Patients With Schizophrenia and Impaired Glucose Tolerance

/psychoses, 4) pregnancy, or 5) a diagnosis of diabetes. Subjects on other dopamine agonists or on medications that may interact with bromocriptine and those taking corticosteroids or other medications that

antipsychotics
schizophrenia 2
insulin resistance
prolactin
fasting
  • 0 views
  • 06 Feb, 2022
  • 1 location
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers

42 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan. On Day 2 they will receive repetitive transcranial magnetic stimulation (rTMS) targeting a specific part of the brain called the dorsal anterior …

Accepts healthy volunteers
traumatic brain injury
  • 10 views
  • 06 Oct, 2021
  • 1 location
Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia

The investigators aim to determine the effect of suvorexant on actigraphically-derived total sleep time in patients with effectively treated restless legs syndrome with persistent insomnia in a two-arm, double-blind, randomized placebo-controlled crossover 2.5-month trial.

wake after sleep onset
suvorexant
restless legs syndrome
total sleep time
insomnia
  • 20 views
  • 09 Sep, 2021
  • 1 location
Dopamine Effect on Inhibitory Control (DEI)

The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications. A key confounding factor of many previous studies is that they did not take the disease duration in consideration. In fact, in moderate-to-advanced stages of …

Accepts healthy volunteers
dyskinesia
dopamine agonists
levodopa
dopa
  • 0 views
  • 02 Jun, 2022
  • 1 location