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Found 118 clinical trials
Featured trial
TemPo Studies  

If you or a loved one have been diagnosed with Parkinson’s disease (PD), you or your loved one may be interested in participating in one of the TemPo Studies. They are a suite of three clinical research studies evaluating an oral investigational drug (Tavapadon) to see if it may help …

  • 127 views
  • 20 Jul, 2023
  • 160 locations
Featured trial
A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 629 views
  • 08 Nov, 2020
  • 1 location
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement (CRC289A07)

studies show reduced reward processing in clinical and subclinical depression, presumably due to abnormalities in the dopamine (DA) system. Here, the investigators will test whether expectation-induced

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall

  • 24 views
  • 04 Oct, 2022
  • 4 locations
[C-11]NPA PET-amphetamine in Cocaine Use Disorders

This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders

  • 0 views
  • 08 Jul, 2022
  • 1 location
Does Caffeine Facilitate Human Reward Learning Behaviors? (ADoRe)

affecting the brain and nervous system. By such effects, caffeine enhances reward signals - dopamine - in human brains. In this research study, we will find out whether taking caffeine acutely or daily can

Accepts healthy volunteers
  • 0 views
  • 02 Sep, 2023
  • 1 location
The Effect of Guanfacine on Delirium in Critically Ill Patients

cost, increased ventilator days, and long-term cognitive disability. Various pharmacologic agents including dopamine antagonists, acetylcholinesterase inhibitors, melatonin, antipsychotics, alpha-2

  • 17 views
  • 26 Nov, 2021
  • 1 location
Apomorphine in Severe Brain-injured Patients (APODoC)

challenging because of scarce and inefficient therapeutical options. Among pharmacological treatments, apomorphine, a potent direct dopamine agonist, has exhibited promising behavioral effects, but its true

  • 0 views
  • 20 Apr, 2022
  • 1 location
Effect of Positive Therapeutic Communication on Pain (POPAIN)

modulation networks decreases transmission in the pain pathways, thus leading to a release of dopamine in the striatum. This technique has already shown to be of benefit in patient management in various

  • 0 views
  • 07 Apr, 2023
TAME-PD - Physical Therapy, Atomoxetine and, Methylphenidate, to Enhance Gait and Balance in Parkinson's Disease (TAME-PD)

Gait and balance problems are a significant source of disability in patients with Parkinson disease. Physical therapy remains one of the main treatments. On the other hand some medications, such as methyphenidate and atomoxetine, have been tried with promising results. The outcomes in gait and balance in Parkinson disease after …

medication regimen
  • 23 views
  • 23 Mar, 2022
  • 1 location