Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 195 clinical trials
featured
Neurovascular effects of dopamine replacement therapy in Parkinson's disease

The goal of this research study is to understand the evolution of levodopa-induced dyskinesias (LID), a refractory and disabling side effect of the gold standard treatment of Parkinson's disease, in hopes of identifying information that can help slow or prevent the development of LID in future patients.  

levodopa
carbidopa
  • 97 views
  • 13 Aug, 2020
  • 1 location
featured
A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 558 views
  • 08 Nov, 2020
  • 1 location
Evaluation of Early CRRT InTerventions in Patients With ECMO(ELITE)

Extracorporeal membrane oxygenation (ECMO) is of great value in supporting patients with cardiac shock. More than 80% ECMO patients will develop renal catastrophe that continuous renal replacement therapy (CRRT) is required. The evidence is conflict as to whether early CRRT improves outcomes. Early CRRT before a definite indication developed may …

  • 0 views
  • 23 Jan, 2021
  • 1 location
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.

Dopamine (DA) plays a critical role in nicotine (and other) addiction and this drug is known to release DA in brain areas mediating reward and motivational processes. Although imaging

dopamine
brain imaging
addiction
bupropion
  • 112 views
  • 07 Nov, 2020
  • 1 location
The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

The purpose of this study is to examine the effect of dopamine infusion and dopamine-2 receptor blockade on pulmonary capillary blood volume, diffusion, and the hemodynamic variables of

  • 35 views
  • 27 Jan, 2021
  • 1 location
Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa

suggested altered reward processing in AN. The neurotransmitter dopamine has a central role in the reward circuitry to drive food approach, and the dynamic interplay between dopamine receptor response and

  • 0 views
  • 26 Jan, 2021
  • 1 location
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall

  • 0 views
  • 24 Jul, 2021
  • 4 locations
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System

investigators work suggests that the brain dopamine (DA) system may be a source of this protective capacity. Investigators have also shown that lower levels of dopamine are associated with slow walking

  • 0 views
  • 18 Jun, 2021
  • 1 location
Phase 1 Safety and Tolerability Study of MSK-DA01 Cell Therapy for Advanced Parkinson's Disease

This clinical trial is designed to test whether surgically injecting nerve cells that make dopamine into the brain of Parkinson's disease patients is safe, and to monitor for potential side

  • 0 views
  • 01 Jul, 2021
  • 3 locations
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension

Dopamine Beta Hydroxylase (DBH) Deficiency who have been previously stabilized with droxidopa therapy for symptoms of neurogenic orthostatic hypotension (NOH) (dizziness, light-headedness, or feelings that

  • 0 views
  • 27 Jan, 2021
  • 127 locations