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Found 176 clinical trials
Featured trial
Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease

Dopamine neurons made from stem cells are injected into the brain under general anesthesia. Subjects then take medicines to partially suppress their immune system (aimed to prevent the body from

dyskinesia
dopamine
  • 57 views
  • 18 Apr, 2022
  • 2 locations
Featured trial
A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group Study to Compare the Efficacy, Tolerability, and Safety of 3 Doses of Gabapentin Enacarbil (GSK1838262) With Placebo in the Treatment of Subjects With Moderate-to-Severe Primary Restless Legs Syndrome (RLS)

  • 626 views
  • 08 Nov, 2020
  • 1 location
Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa

suggested altered reward processing in AN. The neurotransmitter dopamine has a central role in the reward circuitry to drive food approach, and the dynamic interplay between dopamine receptor response and

  • 0 views
  • 12 Sep, 2021
  • 1 location
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall

  • 24 views
  • 24 Jul, 2021
  • 4 locations
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement (CRC289A07)

studies show reduced reward processing in clinical and subclinical depression, presumably due to abnormalities in the dopamine (DA) system. Here, the investigators will test whether expectation-induced

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

The purpose of this study is to examine the effect of dopamine infusion and dopamine-2 receptor blockade on pulmonary capillary blood volume, diffusion, and the hemodynamic variables of

Accepts healthy volunteers
  • 35 views
  • 26 Apr, 2022
  • 1 location
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System (RES)

investigators work suggests that the brain dopamine (DA) system may be a source of this protective capacity. Investigators have also shown that lower levels of dopamine are associated with slow walking

  • 0 views
  • 03 Mar, 2022
  • 1 location
[C-11]NPA PET-amphetamine in Cocaine Use Disorders

This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders

  • 0 views
  • 12 Sep, 2021
  • 1 location
Contribution of L-Tyrosine to Human Decision Making in Stressful Situations (TYRO-STRESS)

L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine administration can increase brain dopamine levels and therefore several studies have explored whether tyrosine

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
Phase 1 Safety and Tolerability Study of MSK-DA01 Cell Therapy for Advanced Parkinson's Disease

This clinical trial is designed to test whether surgically injecting nerve cells that make dopamine into the brain of Parkinson's disease patients is safe, and to monitor for potential side

  • 3 views
  • 06 Apr, 2022
  • 3 locations