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Found 20 clinical trials
Blinatumomab Plus HLA-Mismatched Cellular Therapy for Relapsed/Refractory CD19+ ALL

blood mononuclear cells collected via pheresis from a haploidentical family member - the procedure is analogous to giving a donor lymphocyte infusion outside of the setting of an allogeneic stem cell

flow cytometry
cellular therapy
gilbert's syndrome
cytopenias
stem cell transplantation
  • 0 views
  • 14 Feb, 2021
  • 1 location
Haploidentical HCT for Severe Aplastic Anemia

This study is a prospective, single center phase II clinical trial in which patients with Severe Aplastic Anemia (SAA) ) will receive a haploidentical transplantation. The purpose of this study is to learn more about newer methods of transplanting blood forming cells donated by a family member that is not …

fludarabine
cyclophosphamide
ejection fraction
glomerular filtration rate
red blood cell transfusion
  • 5 views
  • 10 Sep, 2021
  • 1 location
CD8 Depleted Non-engrafting HLA Mismatched Unrelated Infusion With MDS and Secondary AML

The purpose of the study is to determine the safety of an investigational treatment for myelodysplastic syndrome (MDS) after the first therapy (such as azacitidine or decitabine) stops working or after progression of MDS to acute myeloid leukemia (AML). Funding source - FDA OOPD.

acute leukemia
acute promyelocytic leukemia
ejection fraction
decitabine
leukemia
  • 0 views
  • 22 Aug, 2021
  • 1 location
Haplocompatible Transplant Using TCR / Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Infants with severe combined immunodeficiency (SCID) have a profound decrease in number and function of immune cells, and therefore remain highly vulnerable to infection. If not corrected this often leads to death. Hematopoietic cell transplantation (HCT) from matched sibling donor is the standard treatment for these patients, unfortunately though; most …

apheresis
thiotepa
ejection fraction
cell transplantation
graft versus host disease
  • 2 views
  • 22 Aug, 2021
  • 1 location
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

The current national acute lymphoblastic leukaemia (ALL) trial in adults investigated whether a low (reduced) intensity chemotherapy regimen prior to transplant could improve the outcome of patients with ALL who are over 40 years of age. The results (60% 2 year survival) are very encouraging but patients who come to …

cyclophosphamide
myeloablative conditioning
remission
hla-a
total body irradiation
  • 22 views
  • 24 Jan, 2021
  • 22 locations
Methods of T Cell Depletion Trial (MoTD)

A multi-centre phase II trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin vs. Calcineurin inhibitor or Sirolimus-based post-transplant cyclophosphamide.

  • 0 views
  • 24 May, 2021
  • 1 location
ASTX727 and Donor Lymphocyte Infusions After Allogenic Stem Cell Transplantation in Very High Risk MDS or AML Patients

Study of early administration of ASTX727 associated with late Donor Lymphocyte Infusions after allogenic stem cell transplantation in very high risk MDS or AML patients

blast cells
cell transplantation
TP53
  • 0 views
  • 26 Jul, 2021
  • 14 locations
Allogeneic Donor Lymphocyte Infusions Combined With Blinatumomab

This phase 2 study is designed to evaluate the safety, tolerability and efficacy of allogeneic donor lymphocyte infusions (DLI) combined with the bispecific T cell engager blinatumomab in B-precursor ALL patients who have mixed chimerism (MC) or are MRD-positive after allogeneic SCT and are refractory to at least one MRD- …

nilotinib
tyrosine
gilbert's syndrome
blinatumomab
dasatinib
  • 6 views
  • 23 Jan, 2021
  • 2 locations
A Clinical Study to Investigate Interferon Gamma (IFN ) Signature in Patients Post HSCT and in Patients With Impaired HSC Proliferation Pre-transplant

Clinical study designed to collect blood for research purposes in patients after hematopoietic stem cell transplantation (HSCT) or in patients with a medical condition where the blood cells production is impaired. The blood samples will be used to study the role of Interferon gamma (IFN) in graft failure or impairment …

  • 0 views
  • 02 Jun, 2021
  • 25 locations
Novel Drugs After Allo-HSCT in Patients With Multiple Myeloma

This is a retrospective observational study of epidemiological surveillance, multicenter, non-profit, spontaneous, Italian on patients submitted to allo-HSCT among Italian Transplant Centers GITMO. This study will evaluate all consecutive adult patients who received novel drugs after hematopoietic stem cell transplantation from related and unrelated donors between January 1, 2009 to …

cell transplantation
  • 0 views
  • 28 Aug, 2021
  • 2 locations