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Found 10 clinical trials
VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema

The American Association of Thoracic Surgery defines empyema as pus in the pleural space. It is a common thoracic surgery presentation with an estimated 65,000 cases occurring annually in the United States. Despite the high prevalence of empyemas, there has been no consensus as to its optimal first line management. …

  • 16 Sep, 2021
  • 1 location
Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

The purpose of this study is to evaluate the efficacy and safety of intrapleural dornase alfa and tPA administered to patients with clinical failure of small-bore chest tube with persistent pleural effusions or malignancy-related loculated effusion to improve pleural drainage.

  • 19 Feb, 2021
  • 1 location
Immune Profile of Saliva and Serum of Patients With Primary Sj gren s Syndrome

frequency of antibodies directed to DNase I in the serum of pSS patients and these antibodies were associated with the presence of the anti-Epstein-Barr (EBV) early antigen diffuse (anti-EA-D). This finding

keratoconjunctivitis sicca
dry eyes
eye drops
  • 25 May, 2021
  • 3 locations
Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma

(DNAse) could reduce DAMPs and NETs-induced lung injury in severe trauma patients under mechanical ventilation in the intensive care unit (ICU). The primary objective is to demonstrate a

mechanical ventilation
pulmonary contusion
ventilator-induced lung injury
assisted breathing
proteolytic enzymes
  • 11 Sep, 2021
  • 1 location
Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)

This study plans to learn more about the effects of Dornase Alfa in COVID19 (coronavirus disease of 2019) patients, the medical condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Dornase Alfa is a FDA-approved drug for the treatment of cystic fibrosis, which facilitates mucus clearance by cutting …

mechanical ventilation
respiratory distress
assisted breathing
  • 01 May, 2021
  • 1 location
Nebulised Dornase Alfa for Treatment of COVID-19

An open-label, randomised, Best-Available-Care (BAC) and historic-controlled trial of nebulised dornase alfa [2.5 mg BID] for 7 days in participants with COVID-19 who are admitted to hospital and are at risk of ventilatory failure (the COVASE study). Controls will include a randomised arm to receive BAC, historic data from UCLH …

PCR test
coronavirus infection
  • 26 Jan, 2021
  • 1 location
Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer

This phase I/II trial studies the side effects of interstitial photodynamic therapy and to see how well it works with standard of care chemotherapy in treating patients with head and neck cancer that has spread to other parts of the body or that has come back. Interstitial photodynamic therapy uses …

  • 05 Mar, 2021
  • 1 location
Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants

Two innovative approaches, pulsatile orocutaneous entrainment of non-nutritive suck via orosensory entrainment (NTrainer) device technology and serial salivary gene expression analyses, will be merged to examine the relation between gene expression, oral somatosensory stimulation, feeding behavior, and neurodevelopmental outcomes at 18 months corrected age (CA) on 180 extremely preterm infants …

  • 01 Jun, 2021
  • 4 locations
Detection of Viral Particels in Urticaria Patients

Blood samples from urticaria patients will be analyzed for viral particles

  • 03 Sep, 2021
  • 1 location
Utility of Primary Glioblastoma Cell Lines

In this study, the characterization of human malignant glioma cell lines is described. After mechanical and enzymatic digestion of glioblastoma human biopsies from Neuromed IRCCS Neurosurgery patients, the investigators analyzed the established cell lines by immunohistochemistry. The investigators have already characterized 10 cell lines and results revealed that not all …

  • 18 Apr, 2021
  • 1 location