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Found 11 clinical trials
Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder

. Some people in this study will receive Perampanel alone and some people will receive Perampanel and Disulfiram, this will be determined by the pharmacy.

alcohol use disorder
hysterectomy
lfts
experimental drug
heavy drinking
  • 0 views
  • 17 Jun, 2021
  • 1 location
CBT-I Augmentation of TOP for Sobriety and Insomnia in AUD

Alcohol Use Disorder (AUD) and insomnia are more prevalent in Veterans than in the general community. Furthermore, insomnia is comorbid in 36-91% of individuals with AUD and jeopardizes recovery by increasing their risk for relapse and complicating their clinical profile. The VA/DoD guidelines recommend four medications for the treatment of …

  • 0 views
  • 19 Aug, 2021
  • 2 locations
Disulfiram and Cisplatin in Refractory TGCTs.

Non-randomized, open-label, single center trial to assess efficacy (as measured by overall response rate (ORR) by RECIST 1.1 of disulfiram and cisplatin in patients with multiple relapsed

cancer chemotherapy
mg++
human chorionic gonadotropin
major surgery
high-dose chemotherapy
  • 15 views
  • 24 Jan, 2021
  • 1 location
Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease

persistent infection and/or post-infectious causes. Recent in vitro studies indicate that disulfiram is effective at killing both the actively replicating and the more quiescent persister forms of Borrelia

  • 542 views
  • 22 Aug, 2021
  • 1 location
A Targeted Real-Time Technology-Supported Intervention for Patients With Alcohol Use Disorder on Disulfiram

) are used for the treatment of AUD, with disulfiram (Antabuse) the oldest and one of the most common. Disulfiram acts as a "psychological deterrent" and causes physiological reactions when taken with

  • 0 views
  • 29 Sep, 2021
  • 1 location
Vinorelbine Cisplatin Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.

This is a proof-of-concept study to define efficacy of vinorelbine, cisplatin, disulfiram and copper in CTC_EMT positive refractory metastatic hormone receptor positive, HER2 negative breast

immunological adjuvant
growth factor
neutrophil count
vinorelbine
platelet count
  • 35 views
  • 14 Mar, 2021
  • 1 location
Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer

The aim of the study is to establish clinical evidence for introducing disulfiram and cooper as an active therapy for metastatic breast cancer upon failure of conventional systemic and/or

major surgery
metastasis
copper
biomarker analysis
cancer
  • 9 views
  • 19 May, 2021
  • 1 location
Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

The proposed phase I/II study of disulfiram (DSF) for patients with presumed glioblastoma multiforme (GBM) based on magnetic resonance imaging (MRI) or biopsy, including administration before

temozolomide
copper
chemoradiotherapy
neutrophil count
BRAF
  • 90 views
  • 02 Nov, 2021
  • 1 location
Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma

This is a phase I, open-label trial of disulfiram in combination with copper gluconate in patients with treatment-refractory multiple myeloma. The trial is designed to assess the Phase 2

anemia
hypercalcemia
platelet count
refractory multiple myeloma
measurable disease
  • 0 views
  • 31 May, 2021
  • 1 location
Disulfiram and Chemotherapy in Treating Patients With Refractory Solid Tumors or Metastatic Pancreatic Cancer

This partially randomized phase I trial studies the side effects and best dose of disulfiram when given together with chemotherapy in treating patients with a solid tumor that does not respond

pancreatic adenocarcinoma
metastatic adenocarcinoma
cervical cap
adenocarcinoma
serum pregnancy test
  • 4 views
  • 19 Jan, 2022
  • 17 locations