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Found 7 clinical trials
Disulfiram and Cisplatin in Refractory TGCTs. (DISGCT)

Non-randomized, open-label, single center trial to assess efficacy (as measured by overall response rate (ORR) by RECIST 1.1 of disulfiram and cisplatin in patients with multiple relapsed

cancer chemotherapy
metastasis
high-dose chemotherapy
germ cell cancer
alpha fetoprotein
  • 15 views
  • 08 Feb, 2022
  • 1 location
Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.

This is a proof-of-concept study to define efficacy of vinorelbine, cisplatin, disulfiram and copper in CTC_EMT positive refractory metastatic hormone receptor positive, HER2 negative breast

breast cancer
immunological adjuvant
vinorelbine
paclitaxel
neutrophil count
  • 37 views
  • 26 Feb, 2022
  • 1 location
Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma (Repurpose-1)

This is a phase I, open-label trial of disulfiram in combination with copper gluconate in patients with treatment-refractory multiple myeloma. The trial is designed to assess the Phase 2

refractory multiple myeloma
bone marrow procedure
anemia
hypercalcemia
platelet count
  • 0 views
  • 10 Mar, 2022
  • 1 location
Phase II Open Labeled Trial of Disulfiram With Copper in Metastatic Breast Cancer (DISC)

The aim of the study is to establish clinical evidence for introducing disulfiram and cooper as an active therapy for metastatic breast cancer upon failure of conventional systemic and/or

biomarker analysis
breast cancer
metastasis
cancer treatment
dna damage
  • 21 views
  • 19 Aug, 2022
  • 1 location
Disulfiram and Chemotherapy in Treating Patients With Refractory Solid Tumors or Metastatic Pancreatic Cancer

This partially randomized phase I trial studies the side effects and best dose of disulfiram when given together with chemotherapy in treating patients with a solid tumor that does not respond

adenocarcinoma
pancreatic adenocarcinoma
neutrophil count
metastatic adenocarcinoma
tubal ligation
  • 4 views
  • 17 Jun, 2022
  • 3 locations
A Targeted, Real-Time, Technology-Supported Intervention for Patients With Alcohol Use Disorder on Disulfiram (Wisepill+SMS)

) are used for the treatment of AUD, with disulfiram (Antabuse) the oldest and one of the most common. Disulfiram acts as a "psychological deterrent" and causes physiological reactions when taken with

  • 0 views
  • 20 Aug, 2022
  • 1 location
Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial) (MEFO)

Clinical studies have shown that patients with right-sided colon cancer have reduced progression-free and overall survival compared to patients with left-sided colon cancer. At the same time, patients with right-sided colon adenomas have a higher risk of developing interval cancers after endoscopic mucosal resection. Dysbiosis and known bacterial drivers play …

  • 0 views
  • 01 Mar, 2022
  • 2 locations