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Found 1936 clinical trials
Copper Concentration and Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840

The main objective of the study is to evaluate the change in liver copper (Cu) concentration following 48 weeks of treatment with ALXN1840 in adult participants with Wilson Disease (WD) who have been previously treated for at least 1 year with standard of care (that is, trientine, penicillamine, or zinc). …

  • 0 views
  • 04 Apr, 2021
  • 8 locations
Rady Children's Institute Genomic Biorepository

Rady Children's Institute for Genomic Medicine (RCI) will collect biological samples (such as blood), derived genomic sequences (from DNA and RNA), and clinical features in a Biorepository as a standardized resource for future research studies. The purpose of the Genomic Institute Biorepository is to provide consented samples and data for …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Health Environment and Action in Louisville (HEAL) Green Heart Louisville Project

The purpose of this study is to examine how the environment and neighborhood characteristics affects the health of the area residents. The study will help determine how changing neighborhood characteristics, such as green space, affect heart health, risk factors for other diseases, sense of well- being or neighborhood cohesion.

  • 8 views
  • 07 Mar, 2021
  • 1 location
Heart Disease of the Small Arteries in Women and Men

Women suffer disproportionately than men from Cardiac Syndrome X ( chest pain in the absence of flow limiting coronary artery stenosis). Coronary microvascular disease is hypothesized to mediate chest pain in this syndrome. This disorder of the small heart vessels (arterioles) compared to the large vessels (arteries) is not diagnosed …

coronary disease
hmg-coa reductase inhibitor
heart disease
angiography
MRI
  • 11 views
  • 25 Jan, 2021
  • 1 location
MyGeneRank: A Digital Platform for Next-Generation Genetic Studies

Many conditions affecting health are caused by a combination of environment, behaviors, and genes. While individuals can alter some factors in their lives to reduce the chances of developing different diseases (e.g., not smoking cigarettes), the contribution from genetic risk encoded by DNA remains with people throughout their lives. Scientists …

coronary disease
hmg-coa reductase inhibitors
myocardial infarction
cholesterol measurement
sudden cardiac death
  • 12 views
  • 28 Mar, 2021
  • 1 location
Using Big Data to Conduct Innovative Cardiovascular Clinical Trials

Traditional randomized clinical trials (RCTs) have provided extremely valuable information on medical therapies and procedures that have changed the way heart diseases are treated. However, despite these contributions, traditional RCTs are costly, the findings may not be applicable to patients unlike those in the study, and the use of trial …

statin
myocardial infarction
cholesterol measurement
hmg-coa reductase inhibitor
heart disease
  • 3 views
  • 23 Jan, 2021
  • 1 location
The Nueva Ecija Cardiovascular Risk Experiment

This study seeks to assess how beliefs about health risks, specifically the risk of cardiovascular disease (CVD), affect health lifestyles and the demand for preventive care in a low-income setting. It also aims to establish the effectiveness of the Package of Essential Noncommunicable Disease Interventions in the Philippines (PhilPEN) in …

stroke
antihypertensive drugs
primary prevention
hypertension
cardiovascular disease
  • 17 views
  • 22 Jan, 2021
  • 1 location
Effectiveness of Routine Measurement of HRQOL

Aim and Objectives: This is an effectiveness-implementation hybrid trial that aims to find out whether the implementation of routine measurement and reporting on the patient's EQ-5D-5L HRQOL data with an electronic platform can improve HRQOL and pain in patients with chronic knee or back problems in primary care. The investigators …

osteoarthritis
back pain
  • 9 views
  • 25 Jan, 2021
  • 1 location
Effects of Message Framing and Time Discounting on Health Communication for Optimum Cardiovascular Disease and Stroke Prevention

Effects of Message framing and Time discounting on heath communication for Optimum Cardiovascular disease and Stroke PreventionEMT-OCSPis a pragmatic, 2 2 factorial, randomized, controlled, observer blinded, multicenter trial with four parallel groups. It aims to determine if risk and intervention communication strategygain-framed versus loss-frame, long-term context versus short-term context and …

diabetes
hypertension
stroke
cholesterol measurement
  • 0 views
  • 01 Feb, 2021
  • 1 location
Children Affected by Rare Disease and Their Families Network

Families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings. The project at hand will test two innovative forms of care (CARE-FAM and WEP-CARE) at 17 sites …

  • 0 views
  • 24 Jan, 2021
  • 30 locations