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Found 11 clinical trials
Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease Type C

Niemann-Pick disease, type C (NPC) is a lethal, autosomal recessive, lysosomal storage disorder characterized by neurodegeneration in early childhood and death in adolescence. NPC results from mutation of either the Niemann-Pick C1 disease (NPC1) (~95% of cases) or NPC2 genes. NPC is characterized by the endolysosomal storage of unesterified cholesterol …

  • 15 Oct, 2020
  • 1 location
  • 25 Nov, 2020
  • 1 location
Intralipid Versus SMOFlipid in HPN Patients

This study will randomize all patients who are new to the Mayo Clinic HPN team to either standard lipid emulsion (Intralipid) or SMOFLipid.

lipid emulsion
  • 26 Jan, 2020
  • 1 location
The Anti-Diabetic and Cholesterol-Lowering Effects of Cinnamon and Cassia Bark

Introduction: According to the World Health Organization (WHO), approximately 150 million people worldwide have type 2 diabetes. Common and cassia cinnamon have been reported to have anti-diabetic and lipid-lowering effects. Objective: To determine if the combination common and cassia cinnamon product Cinnamonforce™ (Cinnamomum verum and C. aromaticum) reduces fasting blood …

cholesterol measurement
low density lipoprotein
cholesterol level
LDL Cholesterol
type 2 diabetes mellitus
  • 07 Nov, 2020
  • 1 location
The BIomarker Guided Study for Depression

The diagnosis of major depression relies on patient reports, and two patients with the same diagnosis might share only one symptom. Thus, a single mechanism is unlikely to underlie a broad descriptive diagnosis such as major depression. Our approach is anchored by a neural circuit taxonomy that proposes distinct biotypes …

functional magnetic resonance imaging
brain imaging
major depressive disorder
  • 22 Mar, 2020
  • 1 location
Laparoscopic Primary Umbilical Hernia Repair With Routine Defect Closure Using Su2ura Approximation Device

Intended Use The Su2ura Approximation Device is indicated for tissue approximation in endoscopic and open surgery for the placement of interrupted or running stitches in soft tissue such as hernia repair Objectives To assess the safety and efficacy of the Su2ura approximation device for the laparoscopic repair of primary umbilical …

  • 25 May, 2020
  • 3 locations
Morbidity Mortality Short and Long-term Survival of Hemodialysis End-stage Kidney Disease Patients in Central Tanzania

Background: In the last 2 decades, Tanzania made great improvements in the renal replacement therapy infrastructure and services. However, renal replacement therapy remains a challenge in the developing world in terms of inadequate renal registries, and limited published literature. Objectives: This study will identify predictors of mortality, identify common causes …

renal replacement therapy
renal failure
kidney replacement
  • 17 Aug, 2020
  • 1 location
Effect of Lumacaftor/Ivacaftor in Children With Cystic Fibrosis Homozygote for F508del on Small Airway Function

To obtain prospective real world data of the effect of lumacaftor/ivacaftor or tezacaftor/ ivacaftor on small airway disease in children aged 6-18 years with cystic fibrosis (CF) homozygous for F508del. The effect of the medication on small airway disease is evaluated by measurement of multiple breath washout (MBW) with its …

  • 16 Nov, 2020
  • 2 locations
Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro and TEG

The purpose of the research is to compare the global and the portal haemostasis during liver transplantation by functional investigations using TEG and ClotPro tests. The study aims at revealing important coagulation-associated links affecting the outcome of the liver transplant surgery.

  • 10 Feb, 2020
  • 1 location
Evaluation of Outcomes From Treatment of Benign or Malignant Gastroesophageal Diseases

This study will be a retrospective chart review of patients who have been diagnosed with benign or malignant pancreatic disease under the practice of Dr. Rohan Jeyarajah, M.D., Dr. Houssam Osman M.D., and Dr. Edward Cho M.D., Sc.M. at Methodist Health System Hospital in Richardson, TX. The Investigators plan to …

  • 29 Nov, 2020
  • 1 location