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Found 56 clinical trials
Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants

The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants

  • 16 May, 2021
  • 18 locations
C-MRI Guidance of Implantable CRT-implantation in Non-ischemic Dilated Cardiomyopathy

Patients with diagnostic CMR images for assessment of LGE/fibrosis and evidence/presence of non-ischaemic myocardial fibrosis/scar will be randomized to the following treatment groups in a 1:1 ratio: ICD group or Optimal HF care group.

  • 29 Jan, 2021
  • 1 location
IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load

Rationale: Parvovirus B19 (PVB19) persistence in the heart has been associated with progressive cardiac dysfunction and evolution to dilated cardiomyopathy. Objective: Whether high dose

ejection fraction
  • 07 Nov, 2020
  • 1 location
Impella CP With VA ECMO for Cardiogenic Shock

has been used across aeitologies including post-myocardial infarction, dilated cardiomyopathy, acute myocarditis and in post-cardiotomy shock. VA ECMO has a number of effects on the circulation

pulmonary congestion
mechanical circulatory support
membrane oxygenation
  • 11 Apr, 2021
  • 1 location
Reversible Pulmonary Artery Banding as Simplified Management of End-stage Dilated Left Ventriculopathy in Early Life

The purpose of this study is to: 1) Remodel and restore left ventricular geometry and function. 2) Avoid the need for mechanical circulatory support (MCS) and/or cardiac transplantation (CT). 3) Confirm the outcomes of a pilot study completed in Germany and reported in The Journal of Heart and Lung Transplantation …

  • 26 Feb, 2021
  • 1 location
Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy

Nonischemic dilated cardiomyopathy is a heterogeneous disease often associated with increased rates of sudden cardiac death. Although many algorithms have been proposed, risk stratification

  • 09 May, 2021
  • 1 location
A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation

This is a randomized, double-blind, placebo-controlled study in patients with dilated cardiomyopathy (DCM) due to a mutation of the gene encoding the lamin A/C protein (LMNA). The study will

implantable cardioverter defibrillator
walk test
c protein
implantable cardioverter-defibrillators
  • 16 May, 2021
  • 256 locations
Evaluate the Safety and Performance of the AccuCinch Ventricular Repair System - The CorCinch-EU Study

This is prospective, non-randomized, single-arm, international, multicenter, clinical safety and performance clinical investigation to evaluate the AccuCinch Ventricular Repair System for the treatment of heart failure, with or without functional mitral regurgitation due to dilated ischemic or non-ischemic cardiomyopathy

mitral valve repair
mitral regurgitation
ejection fraction
functional mitral regurgitation
  • 24 Jan, 2021
  • 29 locations
Magnetocardiography (MCG) Parameters in the Prediction of Future ICD Therapy

A multi-centre observational cohort trial to identify Magnetocardiography (MCG) parameters in the prediction of future ICD therapy. To show a correlation between Arrhythmogenic features on MCG and future ICD therapies seen on ICD interrogation of patients at risk of SCD.

  • 25 Jan, 2021
  • 1 location
Simvastatin Therapy in Patients With Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. About half of patients die or require heart

heart transplantation
medical therapy
heart failure
dilated cardiomyopathy
  • 22 Apr, 2021
  • 1 location