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Found 17 clinical trials
Digoxin Short Term Treatment Assessment Randomized Trial in AHF (DIG-STA-AHF)

> Digoxin processes many characteristics of a beneficial drug for heart failure, however recent publications has rose concerns about its safety profile and therefore decreasing its use.

  • 5 views
  • 23 Feb, 2022
  • 2 locations
Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis

The purpose of this study is to investigate the potential therapeutic effects of the cardiac glycoside digoxin and the secondary bile acid ursodeoxycholic acid (UDCA) on synovial inflammation

DMARD
  • 0 views
  • 20 Apr, 2022
  • 1 location
Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands (DECISION)

Digoxin is the oldest, market-authorized drug for heart failure (HF), and very cheap. A large trial with digoxin, the DIG trial, executed in the early nineties revealed a highly significant

nt-probnp
heart failure
chronic heart failure
digoxin
b-type natriuretic peptide
  • 5 views
  • 16 Mar, 2022
  • 36 locations
Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

with Digoxin or Sotalol (AF without hydrops); Digoxin or Flecainide (SVT without hydrops); and Digoxin plus Sotalol or Digoxin plus Flecainide (SVT with hydrops).

  • 367 views
  • 08 Feb, 2022
  • 18 locations
Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

While there are several completed clinical trials that address treatment strategy in patients with symptomatic and recurrent AF, there are no randomized clinical trials that address treatment for first-detected AF. In usual care, these patients are started on an atrioventricular nodal blocking agent (beta-blocker or non-dihydropyridine calcium channel blocker) along …

fibrillation
dronedarone
beta blockers
stroke
antiarrhythmic drug
  • 0 views
  • 23 Apr, 2022
  • 2 locations
Digoxin Induced Dissolution of CTC Clusters

This single arm therapeutic exploratory study of digoxin in patients with advanced or metastatic breast cancer investigates whether cardiac glycosides are able to disrupt CTC clusters in breast

stage iv breast cancer
breast adenocarcinoma
cancer
adenocarcinoma
renal function
  • 10 views
  • 15 Aug, 2021
  • 1 location
Inhibition of Sterile Inflammation by Digoxin

To investigate the effect of digoxin on pyruvate kinase isoform 2 (PKM2) binding to pro-inflammatory loci and innate immune inflammatory responses in the peripheral blood in healthy subjects.

  • 0 views
  • 25 Jun, 2021
  • 1 location
Digoxin In Treatment of Alcohol Associated Hepatitis

Prospective, single center, open label, randomized controlled trial to determine the feasibility of conducting a future study with respect to patient recruitment, digoxin administration and dose

  • 0 views
  • 02 Dec, 2021
  • 1 location
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression on established standard therapy, …

serum pregnancy test
solid tumour
cancer
  • 8 views
  • 11 Feb, 2022
  • 1 location
FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic Cancer

Purpose: To determine the feasibility and safety of combining digoxin as a modulator of the hypoxia pathway in combination with FOLinic acid, 5-Fluorouracil, IRINotecan and OXaliplatin

cancer chemotherapy
adenocarcinoma
biliary obstruction
leucovorin
fluorouracil
  • 0 views
  • 27 Apr, 2022
  • 1 location