Found 23 clinical trials
Digoxin Short Term Treatment Assessment Randomized Trial in AHF
> Digoxin processes many characteristics of a beneficial drug for heart failure, however recent publications has rose concerns about its safety profile and therefore decreasing its use.
- 3 views
- 04 Aug, 2021
- 2 locations
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g
- 0 views
- 21 Sep, 2021
- 1 location
Role of CYP2B6 CYP3A4 and MDR1 in the Metabolic Clearance of Methadone
The purpose of this study is to determine to what extent CYP2B6, CYP3A4, and MDR1 polymorphisms affect the metabolism of methadone.
- 229 views
- 07 Nov, 2020
- 1 location
Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands
Digoxin is the oldest, market-authorized drug for heart failure (HF), and very cheap. A large trial with digoxin, the DIG trial, executed in the early nineties revealed a highly significant
- 5 views
- 25 Aug, 2021
- 39 locations
Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)
with Digoxin or Sotalol (AF without hydrops); Digoxin or Flecainide (SVT without hydrops); and Digoxin plus Sotalol or Digoxin plus Flecainide (SVT with hydrops).
- 320 views
- 31 Oct, 2021
- 46 locations
Digoxin In Treatment of Alcohol Associated Hepatitis
Prospective, single center, open label, randomized controlled trial to determine the feasibility of conducting a future study with respect to patient recruitment, digoxin administration and dose
- 0 views
- 02 Dec, 2021
- 1 location
Inhibition of Sterile Inflammation by Digoxin
To investigate the effect of digoxin on pyruvate kinase isoform 2 (PKM2) binding to pro-inflammatory loci and innate immune inflammatory responses in the peripheral blood in healthy subjects.
- 0 views
- 25 Jun, 2021
- 1 location
Digoxin Induced Dissolution of CTC Clusters
This single arm therapeutic exploratory study of digoxin in patients with advanced or metastatic breast cancer investigates whether cardiac glycosides are able to disrupt CTC clusters in breast
- 1 views
- 15 Aug, 2021
- 1 location
FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic Cancer
Purpose: To determine the feasibility and safety of combining digoxin as a modulator of the hypoxia pathway in combination with FOLinic acid, 5-Fluorouracil, IRINotecan and OXaliplatin
- 0 views
- 03 Mar, 2021
- 1 location
Phase IB Metformin Digoxin Simvastatin in Solid Tumors
This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression on established standard therapy, …
- 8 views
- 25 Nov, 2021
- 1 location