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Found 24 clinical trials
The TRANSLATE Trial (TRANSLATE)

previously biopsy-naive men being investigated for clinically significant prostate cancer (on the basis of an elevated age-specific PSA, or abnormal digital rectal examination, or MRI-visible lesion). Men

  • 0 views
  • 25 Mar, 2022
bpMRI and Risk Based Shared Clinical Decision Making in Prostate Cancer Diagnosis (multiIMPROD2)

The shortcoming of the pre-biopsy prostate MRI approach is the recommendation to biopsy all men post-MRI even if there is no lesion seen in MRI, ie. risk of PCa is very low. Therefore, the primary objective of this trial is to compare if there is a difference between significant cancer …

digital rectal examination
biopsy of prostate
  • 0 views
  • 28 Feb, 2022
  • 5 locations
Comparative Health Research Outcomes of NOvel Surgery in Prostate Cancer (IP4-CHRONOS)

Men diagnosed with significant cancer confined to the prostate currently undergo radical therapy directed to the whole prostate (radiotherapy or prostatectomy). These provide good cancer control but can cause significant side effects. Focal Therapy involves targeting the cancer alone, whilst leaving healthy prostate gland alone. Case series have shown similar …

cancer
gonadotropin
antiandrogen therapy
androgens
testosterone
  • 13 views
  • 27 Feb, 2022
  • 8 locations
Prostate Screening Study Using MRI in BRCA Carriers

BRCA mutation includes PSA testing and digital rectal examination (DRE), the same as with men in the general population. This study is being done to assess whether there is value in using MRI as

BRCA1
digital rectal examination
transrectal ultrasound
BRCA2
  • 11 views
  • 25 May, 2022
  • 1 location
Transrectal Ultrasound Robot-Assisted Prostate Biopsy

elevated serum prostate-specific antigen (PSA) level and/or abnormal digital rectal examination (DRE). It is estimated that more than 1 million TRUS-guided prostate biopsies are performed annually in the

prostate specific antigen
transrectal ultrasound
biopsy of prostate
  • 13 views
  • 21 Mar, 2022
  • 1 location
Extended Systematic Versus Mri-Assisted pRostate Transperineal Biopsy (SMART)

with or without abnormal digital rectal examination (DRE) will be randomized in a 1:1 manner to MRI-arm or TP-arm. In the MRI-arm, multiparametric MRI prostate will be performed for each subject. MRI

  • 0 views
  • 11 Jul, 2022
  • 5 locations
A Phase II Study to Test the Efficacy of AB928 (Dual Adenosine Receptor Antagonist) and AB122 (a PD1 Checkpoint Inhibitor) in Combination With Short Course Radiotherapy and Consolidation Chemotherapy for Rectal Cancer. (PANTHER)

Enrolled patients will receive upfront (week 1) short-course radiotherapy to gross pelvic disease (25Gy in 5fx) in combination with AB928 (150 mg orally, once daily as part of a continuous dose regimen). This will be followed by consolidation chemotherapy (weeks 3-20) with mFOLFOX x9 cycles in combination with AB928 and …

adenocarcinoma
pelvic radiation
total mesorectal excision
folfox regimen
  • 0 views
  • 06 May, 2022
  • 1 location
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery

This is a prospective phase II study to assess the efficacy and toxicity of HSV-tk+ valacyclovir gene therapy in combination with androgen deprivation therapy, brachytherapy, external beam radiotherapy, and prostatectomy in previously untreated high-risk prostate cancer.

external beam radiotherapy
leuprolide
antiandrogen therapy
androgens
prostatectomy
  • 3 views
  • 15 Feb, 2022
  • 1 location
Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital

This randomized controlled trial aims to compare the rate of perioperative infection complications in transperineal prostate biopsy between the group that receives prophylactic antibiotic and the group that receives placebo. The types of infection studied included bacteriuria, urinary tract infection (UTI), UTI with fever (febrile UTI), and sepsis. This study …

antibiotic prophylaxis
urine culture
antibiotics
fever
sepsis
  • 0 views
  • 12 Aug, 2021
  • 1 location
Digital PET/CT Using [Ga-68]PSMA for Characterization of Prostate Lesions

The purpose of this study is to evaluate a radioactive diagnostic study drug, which is called Gallium-68 Prostate Specific Membrane Antigen ([Ga-68]PSMA) for characterization of prostate abnormalities.

  • 0 views
  • 21 Apr, 2022
  • 1 location