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Found 45 clinical trials
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

confirm the safety and anticipated RP2D of REGN2810 to be given concomitantly with conventionally fractionated or hypofractionated radiation among patients with newly diagnosed diffuse intrinsic pontine

diffuse intrinsic pontine glioma
regn2810
recurrent glioma
re-irradiation
cns neoplasm
  • 24 views
  • 21 Mar, 2022
  • 17 locations
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (HIT-HGG-2013)

) diffuse intrinsic pontine glioma (DIPG) gliomatosis cerebri (GC) For 1.-3. diagnosis has to be confirmed by neuropathological survey, for 4. and 5. diagnosis has to be confirmed by

temozolomide
anaplastic astrocytoma
malignant glioma
astrocytoma
epilepsy
  • 44 views
  • 16 Jun, 2022
  • 46 locations
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

progressive brain cancer (glioblastoma, medulloblastoma, or ependymoma), or newly-diagnosed diffuse intrinsic pontine glioma (DIPG). Statistical analysis will stratify patients based on whether their

ependymoma
immunotherapy agent
karnofsky performance status
indoximod
antiepileptic
  • 0 views
  • 07 Apr, 2022
  • 2 locations
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. It also tests whether combination of selinexor and standard radiation therapy works to

diffuse intrinsic pontine glioma
neutrophil count
lipase
astrocytoma
tumor cells
  • 0 views
  • 02 Jul, 2022
  • 7 locations
9-ING-41 in Pediatric Patients With Refractory Malignancies.

9-ING-41 has anti-cancer clinical activity with no significant toxicity in adult patients. This Phase 1 study will study its efficacy in paediatric patients with advanced malignancies.

monoclonal antibodies
colony stimulating factor
cns tumor
cancer treatment
myelosuppressive chemotherapy
  • 0 views
  • 14 May, 2022
  • 8 locations
Dose Escalation Study of CLR 131 in Children, Adolescents, and Young Adults With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma (CLOVER-2)

The study evaluates CLR 131 in children, adolescents, and young adults with relapsed or refractory malignant solid tumors and lymphoma and recurrent or refractory malignant brain tumors for which there are no standard treatment options with curative potential.

solid tumor
measurable disease
schwartz
karnofsky performance status
lymphoma
  • 166 views
  • 12 Feb, 2022
  • 7 locations
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system in children and young adults with diffuse intrinsic pontine glioma (DIPG

supratentorial tumors
apheresis
diffuse intrinsic pontine glioma
cns tumor
cns disease
  • 8 views
  • 09 May, 2022
  • 1 location
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Patients will receive a vaccine called SurVaxM on this study. While vaccines are usually thought of as ways to prevent diseases, vaccines can also be used to treat cancer. SurVaxM is designed to tell the body's immune system to look for tumor cells that express a protein called survivin and …

diffuse intrinsic pontine glioma
ependymoma
sargramostim
tumor cells
montanide isa-51
  • 0 views
  • 15 Jun, 2022
  • 2 locations
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22

Central nervous system (CNS) malignancies are the second most common malignancy and the most common solid tumor of childhood, including adolescence. Annually in the United States, approximately 2,200 children are diagnosed with CNS malignancy and rates appear to be increasing. CNS tumors are the leading cause of death from solid …

intraarterial cerebral infusion
beam radiation
avastin
cns tumor
astrocytoma
  • 82 views
  • 01 May, 2021
  • 1 location
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

This study will evaluate palbociclib in combination with chemotherapy (temozolomide with irinotecan and/or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors. The main purpose of phase 1 portion of this study is to evaluate the safety of palbociclib in combination with chemotherapy in …

diffuse intrinsic pontine glioma
palbociclib
rhabdoid tumor
biological factors
solid tumor
  • 129 views
  • 09 Jun, 2022
  • 56 locations