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Found 45 clinical trials
A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG

tolerated dose (MTD) or recommended phase 2 dose (RP2D) of MR-Guided Focused Ultrasound (MRgFUS) energy in combination with SONALA-001 in subjects with diffuse intrinsic pontine glioma

  • 0 views
  • 17 Jun, 2022
  • 2 locations
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma

following previous therapies. The general objective of this phase I/II clinical study is (1) to demonstrate that WT1-targeted DC vaccine production and administration in pediatric patients with HGG and DIPG

  • 0 views
  • 28 Sep, 2021
  • 1 location
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (BRAVO)

The standard of care for children with DIPG includes focal radiotherapy (RT) but outcomes have remained dismal despite this treatment. The addition of oral Temozolomide (TMZ) concurrently with

  • 17 views
  • 12 May, 2022
  • 1 location
ONC201 in Pediatric H3 K27M Gliomas

This is a multicenter, open-label, seven arm, dose escalation, phase I study of oral ONC201 in pediatric patients with newly diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) and recurrent

progressive disease
glomerular filtration rate
nitrosoureas
neutrophil count
platelet count
  • 87 views
  • 12 Mar, 2022
  • 8 locations
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy (PEACH)

A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with

bone marrow procedure
colony stimulating factor
granulocyte colony stimulating factor
depo-provera
neutrophil count
  • 0 views
  • 14 May, 2022
  • 2 locations
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

The blood brain barrier (BBB) prevents some drugs from successfully reaching the target source. Convection-Enhanced Delivery (CED) is a method of direct infusion of drugs under controlled pressure to the tumor that may reduce systemic side effects of drugs in the patient. The purpose of this Phase I study is …

anesthesia
neutrophil count
seizures
platelet count
anticonvulsants
  • 1 views
  • 27 Feb, 2022
Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back

glomerular filtration rate
nitrosoureas
neutrophil count
platelet count
recurrent malignant glioma
  • 3 views
  • 21 Apr, 2022
  • 21 locations
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

) including diffuse intrinsic pontine glioma (DIPG) to be in the research, because they have scheduled to have radiation to treat their cancer. The study is divided into two parts. The goal of the

brainstem tumor
neutrophil count
platelet count
dipg
recurrent tumor
  • 1 views
  • 24 Mar, 2022
  • 9 locations
Combination Therapy for the Treatment of Diffuse Midline Gliomas

This phase II trial determines if the combination of ONC201 with different drugs, panobinostat or paxalisib, is effective for treating patients with diffuse midline gliomas (DMGs). Despite years of research, little to no progress has been made to improve outcomes for patients with DMGs, and there are few treatment options. …

  • 1 views
  • 19 Jun, 2022
  • 3 locations
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

This study is for patients with high grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) or medulloblastoma or another rare brain cancer that expresses GD2. Because there is no

cytokines
measurable disease
platelet count
dipg
diffuse intrinsic pontine glioma
  • 1 views
  • 11 Mar, 2022
  • 1 location