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Found 43 clinical trials
Re-Irradiation of Progressive or Recurrent DIPG

This is a single-arm, non-randomized study of re-irradiation of diffuse intrinsic pontine glioma (DIPG)

  • 8 views
  • 24 Mar, 2022
  • 18 locations
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) (KONQUER)

This study will evaluate the safety of BXQ-350 and determine the maximum tolerated dose (MTD) in children with newly diagnosed DIPG or DMG. All patients will receive BXQ-350 by intravenous (IV

  • 0 views
  • 24 Apr, 2022
  • 3 locations
  • 0 views
  • 30 Apr, 2021
  • 8 locations
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive childhood brain tumor that, despite many past clinical trials, has never been shown to respond to chemotherapy. Radiation therapy (RT) is

neutrophil count
platelet transfusion
brain tumor
platelet count
renal function
  • 0 views
  • 24 Mar, 2022
  • 1 location
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma

complex (MHC) molecules on cell surface, thereby activating neoantigen-specific T cells and triggering corresponding cytotoxic T cell immune responses to eliminate H3.3-K27M-expressing DIPG cells. The

  • 0 views
  • 14 Jul, 2021
  • 1 location
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy

even more effective. Thus, the diffuse intrinsic pontine glioma and the medulloblastoma in relapse/progression have been chosen to study the potential of this new advanced therapy through a weekly

  • 0 views
  • 01 Sep, 2021
  • 1 location
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (AflacST1501)

intrinsic pontine glioma (DIPG) (Stratum A) and in relapsed/refractory/progressive malignant brain (Grade III/IV, including DIPG; MBT) and solid tumor (ST) patients (Stratum B).

monoclonal antibodies
platelet count
neutrophil count
platelet transfusion
filgrastim
  • 133 views
  • 19 Apr, 2022
  • 5 locations
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

-shelf neo-antigen heat shock protein containing 16 peptides reflecting neo-epitopes found in the majority of DIPG and DMG tumors. Newly diagnosed patients with DIPG and DMG who have completed radiation

  • 0 views
  • 23 Apr, 2022
  • 1 location
A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma (LoBULarDIPG)

In this study, the investigators are testing improvement in survival outcomes in DIPG patients when stratified with MR perfusion score and treated with the said protocol. Newly diagnosed DIPG

bevacizumab injection
glomerular filtration rate
neutrophil count
bevacizumab
  • 82 views
  • 18 May, 2022
  • 1 location
Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses (DIPG)

Prospective, non-blinded, randomised two cohorts study on the efficacy of two different radiotherapy schedule for DIPG by using the same concomitant and post-radiotherapy systemic treatment.

nimotuzumab
re-irradiation
  • 1 views
  • 12 Feb, 2022
  • 1 location