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Found 63 clinical trials
Effects and Safety of Sacubitril/Valsartan Versus Valsartan on Refractory Hypertension: The EOSORH Trial

Resistant hypertension (RH) accounted for a considerable proportion of patients with hypertension. It has been revealed to impose certain adverse effects on the prognosis of patients with cardiovascular diseases. The antihypertensive effect of sacubitril/valsartan being fully confirmed in previous studies, there were no related randomized controlled trials (RCT) about this …

  • 0 views
  • 19 Oct, 2022
  • 1 location
A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Multicenter Study to Evaluate the Efficacy and Safety of ALN-AGT01 in Patients With Mild-to-Moderate Hypertension (KARDIA-1)

The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.

systolic blood pressure
hypertension
antihypertensive drugs
  • 44 views
  • 25 Oct, 2022
  • 84 locations
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add

olmesartan
amlodipine
hypertension
antihypertensive drugs
  • 8 views
  • 13 Oct, 2022
  • 93 locations
Targeting of UnControlled Hypertension in Emergency Department

blood pressure (DBP) differences at 3-months, and mean DBP differences at 6-months. Additionally improvement in cardiovascular risk score (as measured by the Atherosclerotic Cardiovascular Disease

uncontrolled hypertension
KIT
antihypertensive drugs
hypertension
smoking cessation
  • 0 views
  • 06 Dec, 2021
  • 1 location
Intensive Management of Blood Pressure and Cholesterol in Elderly Chinese With Hypertension and Atrial Fibrillation

Study name: Intensive management of blood pressure and cholesterol in elderly Chinese with hypertension and atrial fibrillation (IMPRESSION) Medicine: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); allisartan (240mg/tablet). Rationale: controlling blood pressure and cholesterol are both effective means to reduce cardiovascular risks, however, it is still unknown whether high cardiovascular risk …

atorvastatin
antihypertensive drugs
hypertension
cholesterol level
amlodipine
  • 0 views
  • 18 Dec, 2021
  • 1 location
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department (MIBORED)

Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml or 100 ml, can predict fluid responsiveness in spontaneously breathing patients with hemodynamic instability.

  • 0 views
  • 27 May, 2022
  • 1 location
Danish Cardiovascular Screening Trial II (DANCAVAS-II)

This study attempts to reduce social inequality in cardiovascular health by performing an interventional screening trial on how best to decrease cardiovascular disease (CVD) among people with low social status.

cardiovascular disease
  • 13 views
  • 06 Feb, 2022
  • 4 locations
Mechanisms of EPO-induced Hypertension (EPIC)

The investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP). The

erythropoietin
anemia
hypertension
darbepoetin alfa
renal disease
  • 0 views
  • 23 Mar, 2022
  • 1 location
Single-center Prospective Clinical Trial to Validate the Performance of the Aktiia Optical Blood Pressure Monitoring (OBPM) Device at the Wrist Against Double Auscultation

accuracy of Aktiia.product-us systolic and diastolic blood pressure measurements against double-auscultation reference measurements. In order to induce blood pressure changes and to simulate ambulatory

Accepts healthy volunteers
blood pressure diastolic
  • 0 views
  • 25 Oct, 2022
  • 1 location
Early Vascular Adjustments During Hypertensive Pregnancy

antihypertensive therapy (with target systolic and diastolic blood pressure <130/80mmHg), prevents the progression to severe hypertension and/or preeclampsia compared to no treatment, without the alleged side

diastolic blood pressure
methyldopa
hypertension
antihypertensive drugs
antihypertensive therapy
  • 20 views
  • 01 Apr, 2021
  • 1 location