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Found 30 clinical trials
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Respiratory Muscle Function in Heart Failure

This study is being done because investigators are trying to determine how respiratory muscle and lung function influence the exercise responses in heart failure and healthy participants. Further, the heart failure patients will participate in an intervention to improve their respiratory muscle function to determine if this improves exercise capacity.

Accepts healthy volunteers
  • 1 views
  • 09 Jan, 2022
  • 1 location
None
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.

heart failure with preserved ejection fraction
diastolic dysfunction
ejection fraction
dyspnea
  • 0 views
  • 02 Jun, 2021
  • 1 location
None
Mechanisms of Right Ventricular Adaptation in Patients With Heart Failure With Preserved Ejection Fraction

Biventricular PV-loop studies and advanced imaging to assess left-to-right ventricular interaction in HFpEF: In a group of 30 HFpEF patients with clinical indication for LH/RH catheter investigation, we will perform biventricular PV loop assessment in combination with extensive imaging (MRI, echo) for in-depth analysis of left-to-right ventricular interaction in the …

heart failure with preserved ejection fraction
medical therapy
ejection fraction
  • 3 views
  • 25 Jan, 2021
  • 2 locations
None
Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction

A 35-week, single-center, prospective, double-blind, controlled, randomized, 2x2 crossover, interventional Phase II study, investigating the effect of treatment with dapagliflozin 10mg od on Left Ventricular distensibility in patients with early HFpEF.

heart failure with preserved ejection fraction
stiffness
chronic heart failure
ejection fraction
diuretics
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
sPERMIdine supplemenTation on Metabolic Neuronal and Cardiovascular Response to Exercise TRAINING

This study explores whether spermidine supplementation improves the metabolic, neurological-cognitive and cardiovascular response to structured exercise training in patients with heart failure with preserved ejection fraction. The investigators aim to show that a faster adaptation to exercise may improve long term adherence to a more active lifestyle.

  • 1 views
  • 28 Nov, 2021
  • 1 location
None
Physiologic Accelerated Pacing as a Treatment in Patients With Heart Failure With Preserved Ejection Fraction

Part I: Week 0-12: Quantify the effects of lower heart rate (HR) elevation on symptoms and function in patients with heart failure with preserved ejection fraction (HFpEF). The investigators hypothesize that a personalized lower HR elevation employing physiological conduction system pacing in patients with HFpEF will decrease left atrial and …

  • 0 views
  • 04 Mar, 2021
  • 1 location
None
Hemodynamic-GUIDEd Management of Heart Failure

The GUIDE-HF IDE clinical trial is intended to demonstrate the effectiveness of the CardioMEMS™ HF System in an expanded patient population including heart failure (HF) patients outside of the present indication, but at risk for future HF events or mortality.

medical therapy
nesiritide
ejection fraction
pro-brain natriuretic peptide
nt-probnp
  • 677 views
  • 12 Jan, 2022
  • 126 locations
None
Cardiac Resynchronisation Therapy Versus Rate-responsive Pacing in Heart Failure With Preserved Ejection Fraction

Half of patients with heart failure have normal heart pumping function (Heart failure with Preserved Ejection Fraction, HFpEF), most commonly characterised by breathlessness on exercise. A number of mechanisms are responsible, but frequently patients are unable to raise their heart rate on exercise. This can be treated by a 'rate-responsive …

heart failure with preserved ejection fraction
ejection fraction
atrio-biventricular pacing
cardiac resynchronization therapy
evidence based treatment
  • 0 views
  • 05 Aug, 2021
  • 2 locations
None
CORolla TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)

The study objective is to demonstrate safety and feasibility of the CORolla TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with heart failure and preserved ejection fraction.

heart failure with preserved ejection fraction
ejection fraction
cardiomyopathy
heart disease
heart failure
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function

Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory and anti-arrhythmic effects. In previous studies from our laboratory, we found that LLTS significantly suppressed atrial fibrillation (AF) inducibility and decreased AF …

Accepts healthy volunteers
ejection fraction
fibrillation
electrocardiogram
paroxysmal atrial fibrillation
  • 0 views
  • 27 Dec, 2021
  • 1 location