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Found 35 clinical trials
Hemodynamic Effects of Pressure-regulated Volume Control Mode in Patients With Diastolic Dysfunction Undergoing Radical Cystectomy

. Up to investigator knowledge, the effect of mechanical ventilation on patient hemodynamics is still unclear especially in patients with diastolic dysfunction. The optimal ventilation mode for

  • 0 views
  • 21 Mar, 2022
  • 1 location
ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation

The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). …

heart failure
valsartan
sacubitril
natriuretic peptide
hypertension
  • 6 views
  • 08 Nov, 2020
  • 1 location
MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women

In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function.

Accepts healthy volunteers
antioxidants
mitoquinone
  • 48 views
  • 04 Oct, 2022
  • 1 location
Teneligliptin on the Progressive Left Ventricular Diastolic Dysfunction With Type 2 Diabetes Mellitus Study (TOPLEVEL)

This is the clinical trial designed to assess the cardiac diastolic function of long term treatment with teneligliptin compared to that without teneligliptin in patients with type 2 diabetes mellitus by two arms; one includes patients showing E/e' by echocardiography less than 8, the other includes patients showing E/e' by …

antidiabetic agents
  • 7 views
  • 13 Feb, 2022
  • 1 location
Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis

The purpose of this study is to examine the impact of early surgery in patients with asymptomatic severe aortic valve stenosis with signs of subclinical LV dysfunction despite preserved LVEF, with a watchfull waiting approach.

heart surgery
aortic valve stenosis
stenosis
aortic valve replacement
  • 0 views
  • 25 Jan, 2021
  • 1 location
Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI (ARNiAMI)

This study examines the effect of Entresto on central hemodynamic parameters during exercise in patients with diastolic dysfunction following acute myocardial infarction. Half of the patients

entresto
valsartan
myocardial infarction
infarct
revascularisation
  • 0 views
  • 16 Feb, 2022
  • 1 location
CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)

The study objective is to demonstrate safety and feasibility of the CORolla TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with heart failure and preserved ejection fraction.

ejection fraction
right heart catheterization
diastolic dysfunction
heart failure
heart disease
  • 0 views
  • 25 Jan, 2022
  • 1 location
Compare the Efficacy and Safety of Rosuvastatin/Ezetimibe Combination Therapy Versus Rosuvastatin Monotherapy in Korean Patients With Left Ventricular Diastolic Dysfunction and Hyperlipidemia

improvement of diastolic dysfunction, VAC index, peak VO2, distance of 6 minute working test, and clinical outcomes including death, readmission rate.

  • 0 views
  • 03 Feb, 2021
  • 1 location
Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)

The purpose of the study is to evaluate the presence of early vascular aging 6 months and 12 months after COVID-19 infection.

Accepts healthy volunteers
  • 0 views
  • 28 Nov, 2021
  • 3 locations
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES (CardiacAging)

Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral …

Accepts healthy volunteers
  • 0 views
  • 07 Oct, 2022
  • 1 location