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Found 61 clinical trials
Neurologic Stem Cell Treatment Study (NEST)

This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain neurologic conditions. …

  • 04 Oct, 2022
  • 3 locations
Deprescription of Gabapentinoids in Medical Inpatients (GABA-WHY)

In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care hospitals in Montréal, Canada. This intervention will be supplemented by a brief information session for medical staff on the wards. This study …

  • 26 Apr, 2022
  • 2 locations
BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome (INjECT)

The main purpose of the study is to assess the safety and efficacy of repeated administrations of BoNT-A in subjects with NP attributable to carpal tunnel syndrome (CTS) through a randomized, double-blind, placebo-controlled study. Further research has shown that BoNT-A has analgesic properties independently from its action on muscle tone, …

peripheral neuropathic pain
nerve conduction
drug test
  • 18 Jun, 2022
  • 1 location
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? Does exposure to high glucose impair autophagy and …

Accepts healthy volunteers
  • 11 Apr, 2023
  • 1 location
Objective Measures of Nerve Integrity Posture Gait and Blood Flow After Nerve Decompression

The purpose of this study is to measure the effect of nerve decompression on the recovery of the treated nerves. To obtain objective data during surgery of the treated nerves' via electrical signals and muscle power when stimulated. Also, to monitor muscle strength, balance/gait and blood flow in the lower …

nerve decompression
  • 22 Feb, 2021
  • 1 location
Prospective Evaluation of NfL as a Biomarker in ATTRv (NfLInATTRv)

ATTR amyloidosis is a rare and progressively disabling disease caused by the deposition of misfolded TTR protein in multiple tissues including the nerves, heart, and gastrointestinal tract. Polyneuropathy (PN) and cardiomyopathy (CM) are the two most frequent phenotypes and many patients presented a mixed picture of PN and CM. There …

  • 16 Sep, 2023
Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes (DM PAD)

In the UK there are over 7,000 leg amputations each year because of diabetes. The most important cause of this is poor circulation. The detection of poor circulation in patients with diabetes is difficult. A number of tests exist to detect poor circulation (known as peripheral arterial disease (PAD)). However, …

arterial disease
  • 09 Sep, 2023
  • 15 locations
RECCORD (Recording Courses of Vascular Diseases) Registry (RECCORD)

The RECording COurses of vasculaR Diseases registry (RECCORD registry) is an observational, prospective, multicentre, all-comers registry platform. In the initial phase, patients referred for endovascular revascularization of peripheral artery disease (PAD) of the lower limbs will be prospectively included and followed up for at least one year. At baseline, data …

endovascular revascularization
vascular disease
endovascular intervention
peripheral artery disease
  • 27 Feb, 2022
  • 1 location
A Real World Observational Registry of Chronic Wounds and Ulcers

More than 100 hospital based outpatient wound centers in the USA and Puerto Rico agree to transmit structured data on all patients followed with chronic wounds and ulcers (e.g. diabetic foot ulcers, venous ulcers, pressure ulcers, arterial ulcers, surgical wounds, and traumatic wounds). Data are collected at point of care …

decubitus ulcer
compression therapy
foot ulcer
foot ulceration
pressure ulcer
  • 22 Jan, 2021
  • 1 location
Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients

The aim of the prospective observational GDC-Study in patients with newly diagnosed diabetes mellitus aged 18-69 years at inclusion into the study is to characterize in detail the clinical, metabolical and immunological phenotype and monitor the progression of the disease and to compare the phenotype to glucose tolerant humans of …

  • 21 Jan, 2021
  • 1 location