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Found 68 clinical trials
Surgical or Medical Treatment (ST2OMP)

This study will test the hypothesis that metabolic bariatric surgery will be more effective at providing durable glycemic control and reduce co-morbidities than intensive medical therapy in youth with type 2 diabetes.

metformin
bariatric surgery
diabetes
type 2 diabetes mellitus
insulin
  • 22 views
  • 04 Oct, 2022
  • 2 locations
Resveratrol and Vascular Function in CKD

The proposed research is clinical study evaluating the therapeutic benefits of resveratrol on vascular function in patients with chronic kidney disease (CKD). The study aims to establish that resveratrol will improve endothelial function and functional performance by reducing oxidative stress and in conjunction with lowering markers of inflammation and oxidative …

nephropathy
diabetes
type 2 diabetes mellitus
angiotensin
angiotensin converting enzyme
  • 10 views
  • 10 Jul, 2022
  • 1 location
Tangningtongluo Tablet for People With Prediabetes

Prediabetes is an intermediate transition to hyperglycemia between normal blood glucose and diabetes, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT)and the presence of a combination of the two. At present, the prediabetes population in China is very large. Timely detection of this sub-health population and effective intervention are …

fasting
hyperglycemia
diabetic retinopathy
insulin resistance
retinopathy
  • 0 views
  • 07 Apr, 2022
  • 1 location
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent Probiotics in CKD Patients With PAD

Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD). Retention of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and trimethylamine N-oxide (TMAO) during CKD is detrimental to endothelial and vascular function and can predispose to the development and …

  • 0 views
  • 15 Mar, 2021
  • 1 location
Efficacy, Mechanisms and Safety of SGLT2 Inhibitors in Kidney Transplant Recipients (INFINITI2019)

This study will be a randomized, double-blind, placebo-controlled clinical trial comparing the SGLT2 inhibitor dapagliflozin to placebo in 52 kidney transplant recipients (KTR) with pre-existing type. diabetes (T2D) or post-transplant diabetes mellitus (PTDM). The primary outcome of the trial is to determine if dapagliflozin is superior to placebo in reduction …

hemoglobin a1c
  • 0 views
  • 24 Mar, 2022
Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension (Ang(1-7))

In this study, we will assess the change of serum ACE-2, angiotensin(1-7), and vascular function after using olmesartan (an ARB), compared to conventional anti-hypertensive drug, amlodipine in hypertensive patients with T2DM.

hypertension
diabetes
olmesartan
blood pressure diastolic
amlodipine
  • 0 views
  • 04 Oct, 2022
  • 1 location
Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS)

In an investigator initiated multicenter trial (Malm, Odense, rhus) the investigators aim at evaluating activity of Gravesophthalmopathy (GO) and progress to severe GO in patients with mild to moderate Graves ophthalmopathy treated with simvastatin or no treatment.

thyroidectomy
exophthalmos
graves' disease
hyperthyroidism
thyroxine
  • 53 views
  • 27 Feb, 2022
  • 1 location
Impact of the SGLT2 Inhibitor Empagliflozin on Urinary Supersaturations in Kidney Stone Formers

The aim of this study is to test the effect of a new drug on the composition of the urine in kidney stone patients. This new drug (Jardiance, substance: empagliflozin) is currently approved in Switzerland for the treatment of patients with diabetes. Data from previous studies with and without diabetes …

Uric Acid Test
diabetes
  • 0 views
  • 05 Nov, 2021
  • 1 location
Home-based Interventions for FrAilty preveNTion in AdultS With DIabeTes and Chronic Kidney Disease (Fantastic)

One of the most common problems in people with diabetes (DM) and chronic kidney disease (CKD) is the high frequency of other coinciding medical conditions such as osteoporosis and frailty. Frailty in particular is very common in adults with DM and CKD and it can result in significant muscle weakness …

diabetes
  • 0 views
  • 07 Oct, 2022
  • 1 location
Repository of Novel Analytes Leading to Autoimmune, Inflammatory and Diabetic Nephropathies (RENAL AID) (RENAL AID)

A central goal of this data repository is to collect data from a large population of subjects with a variety of renal disease states. Cohorts will include subjects with diabetes, inflammatory/autoimmune and transplant related renal conditions. Additionally, the repository will have the capacity to store biospecimens and electronic data in …

biological factors
biopsy tissue
nephropathy
kidney biopsy
kidney transplant
  • 97 views
  • 11 Oct, 2022
  • 1 location