Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 68 clinical trials
A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes (PERL-FENO)

Diabetic kidney disease remains the leading cause of end-stage kidney disease (ESKD), rising in frequency in parallel with the epidemic of diabetes worldwide. The estimated lifetime risk of

renin
insulin
diabetes
angiotensin
microalbumin/creatinine ratio
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes (ACTIDIANE)

Type 2 diabetes is a chronic condition whose prevalence is increasing globally. Kidney disease is a key complication of diabetes and is among the most common cause of end-stage renal disease, requiring renal replacement therapy. It has been shown that the trajectory of renal function (estimated glomerular filtration rate eGFR) …

nephropathy
diabetes
type 2 diabetes mellitus
renal failure
replacement therapy
  • 13 views
  • 03 Mar, 2022
  • 17 locations
Could Ketoanalogue-supplemented Low Protein Diet Defer Dialysis in Advanced Diabetic Kidney Disease? (K-DDD) (K-DDD)

This is a prospective single center open label randomized controlled trial aiming to assess the effectiveness and safety of a low protein diet (0.6 g/kg-day, mainly vegetarian) supplemented with ketoanalogues of essential amino-acids (sLPD) as compared to a mild protein restriction (0.8 g/kg-day, MPD) in reducing Chronic Kidney Disease (CKD) …

  • 2 views
  • 28 Feb, 2022
  • 1 location
Safety and Efficacy of Maximally Tolerated RAAS Blockade and Spironolactone Therapy on Urinary Proteinuria and Progression of Type II Diabetic Nephropathy in African Americans and Other Patient Cohorts. (MRA-ACE)

NephroNet proposes to examine whether combining Spironolactone with maximal RAAS blockade will further reduce urinary protein at one year and whether prolonged therapy (24 months) is able to slow the decline in GFR. Because of combination MRA and RAAS therapy significantly increases the risk for clinically significant hyperkalemia, we also …

proteinuria
diabetes
type 2 diabetes mellitus
renal function
angiotensin
  • 34 views
  • 13 Oct, 2022
  • 2 locations
Frailty, Inflammation, and Stem Cell Functionality in Chronic Kidney Disease

The proposed studies will examine the effect of fisetin on adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, markers of inflammation, and physical function in individuals with advanced chronic kidney disease.

nephropathy
diabetes
diabetes mellitus
chronic disease
glomerular filtration rate
  • 66 views
  • 13 Oct, 2022
  • 1 location
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD (ESTEEM-VIDA)

Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death. Sarcopenia in this proposal is defined by impaired metabolism and physical function associated with decreased skeletal muscle mass or function. Skeletal muscle tissue relies on mitochondria to efficiently …

  • 15 views
  • 05 May, 2022
  • 1 location
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy (RAISE-KT)

This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or dialysis-dependent end-stage kidney disease (ESKD) on patients' eligibility for kidney transplantation at the end of 9 months.

dialysis
kidney transplant
diabetes
type 2 diabetes mellitus
microalbumin/creatinine ratio
  • 0 views
  • 24 Mar, 2022
  • 1 location
Effects of Multidisciplinary Intensive Targeted Care in Improving Diabetes Outcomes: a Pilot Study in Singapore (IDEALS)

This study aims to investigate whether channeling purposefully structured resources to patients at high risk of developing diabetic complications to interdisciplinary team clinic consultations, interspersed with closer remote follow-up and aided by simple technology will be more effective than usual care in controlling diabetes mellitus, controlling multiple cardiovascular risk factors …

glycosylated hemoglobin
diabetes
diabetic complication
self monitoring
hypertension
  • 8 views
  • 07 Feb, 2022
  • 1 location
Uric Acid Lowering Trial in Youth Onset T2D (ULTRA-T2D)

diabetic kidney disease (DKD) in youth with T2D over 7 years follow-up. Elevated SUA is thought to lead to cardiovascular disease (CVD) and DKD by inflammation, mitochondrial dysfunction and deleterious

nephropathy
diabetes
type 2 diabetes mellitus
urate oxidase
Uric Acid Test
  • 1 views
  • 22 Mar, 2022
  • 1 location
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.

The purpose of this study is to evaluate the potential benefits of 145 mg of daily fenofibrate in adults with type 1 diabetes mellitus and pre-existing non-proliferative diabetic retinopathy.

retinopathy
diabetes
fasting
diabetic retinopathy
insulin
  • 22 views
  • 21 Jun, 2021
  • 21 locations