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Found 68 clinical trials
Randomised, Double-blind (Within Dose Groups), Placebo Controlled and Parallel Group Trial to Investigate the Effects of Different Doses of Oral BI 685509 Given Over 20 Weeks on UACR Reduction in Patients With Non-diabetic Kidney Disease

This study is open to adults who have kidney disease that is not caused by diabetes. The purpose of the study is to find out whether a medicine called BI 685509 improves kidney function. Three different doses of BI 685509 are tested in this study. Participants get either one of …

  • 32 views
  • 27 Oct, 2022
  • 78 locations
A Phase 2b Multicentre, Randomised, Double-Blind, Active-Controlled, Parallel Group Dose-Ranging Study to Assess the Efficacy, Safety and Tolerability of Zibotentan and Dapagliflozin in Patients With Chronic Kidney Disease With Estimated Glomerular Filtration Rate (eGFR) ≥ 20 mL/Min/1.73 m^2 (ZENITH-CKD)

The purpose of the study is to assess efficacy, safety and tolerability of treatment with zibotentan and dapagliflozin in combination and dapagliflozin 10 mg as monotherapy in participants with chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) ≥ 20 mL/min/1.73 m^2, and urinary albumin to creatinine ratio (UACR) …

  • 91 views
  • 10 Oct, 2022
  • 99 locations
Blood Pressure Control for Type 2 Diabetes (BM4DM)

The BP4DM study was initiated as a prospective randomized controlled trial to investigate the renal protection effect for tight blood pressure control for Taiwanese T2DM patients without previously diagnosed CV events. We set our primary outcome for the prevention of microalbuminuria development. The secondary outcomes include mortality, annual renal function …

type 2 diabetes mellitus
hypertension
kidney function tests
diabetes
behavior modification
  • 20 views
  • 02 Mar, 2022
  • 2 locations
SER150 vs Placebo in Diabetic Kidney Disease

This study is to assess the efficacy, safety and pharmacokinetic (PK) of SER150 administered for 12 weeks as a 15 mg twice a day (BID) dose in participants with type 2 diabetes (T2D) and macroalbuminuria in treatment with either an angiotensin converting enzyme inhibitor (ACEI) or an angiotensin receptor antagonist …

glycosylated hemoglobin
glycated hemoglobin
angiotensin converting enzyme
antidiabetics
diabetes
  • 0 views
  • 29 May, 2022
  • 4 locations
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease

stem/stromal cells (MSC) in patients with progressive diabetic kidney disease (DKD).

hypertension
renal failure
nephropathy
diabetes
dialysis
  • 85 views
  • 17 Feb, 2022
  • 1 location
  • 0 views
  • 01 Jul, 2022
  • 1 location
Efficacy, Safety and Response Predictors of Adjuvant Astragalus Therapy for Diabetic Kidney Disease (READY)

This add-on open-label randomised controlled pragmatic trial aims to: evaluate the effect of add-on astragalus treatment on type 2 diabetic patients with stage 2 to 3 chronic kidney disease and macroalbuminuria. estimate treatment effect, variance, recruitment rate, attrition rate and change in clinical manifestation including Chinese medicine syndrome for parameters …

angiotensin converting enzyme
diabetic nephropathy
angiotensin
insulin
type 2 diabetes mellitus
  • 35 views
  • 15 Feb, 2022
  • 1 location
Basic Needs Navigation Intervention to Address Multidimensional Adversity in African Americans With Diabetic Kidney Disease

of life in low-income African Americans with diabetic kidney disease (DKD) experiencing multidimensional adversity. The study objective will be achieved with the following aims: Aim 1

diabetes
hemoglobin a1c
  • 0 views
  • 07 Oct, 2022
  • 1 location
Study on the Efficacy and Safety of a Novel Tripterygium Wilfordii Preparation in Reducing Proteinuria in Patients With Diabetic Nephropathy

The investigators designed a randomized parallel controlled clinical study, selected 98 cases of diabetic nephropathy patients with urinary protein > 1g, randomly assigned into the Kunxian

irbesartan
immunosuppressants
proteinuria
glomerular filtration rate
  • 0 views
  • 09 May, 2022
  • 1 location
Dosimetry of Tc-99m-Tilmanocept

and can thus be used for future trials evaluating early diagnosis and treatment of diabetic nephropathy.

diabetes
Accepts healthy volunteers
  • 0 views
  • 14 Mar, 2022
  • 1 location