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Found 9 clinical trials
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Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery

infants. The investigators are testing Dexrazoxane, which has proven to be cardio-protective in pediatric cancer patients, in the hope that it may lessen cardiac injury during and after congenital heart

  • 0 views
  • 20 Aug, 2021
  • 1 location
None
Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane

The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.

  • 0 views
  • 14 Jun, 2021
  • 1 location
None
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with CPX-351 and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by …

cytarabine
cytarabine/daunorubicin
mitoxantrone
cancer
cell transplantation
  • 5 views
  • 27 Oct, 2021
  • 95 locations
None
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

topotecan
shortening fraction
doxorubicin
mycn protein
cyclophosphamide
  • 66 views
  • 03 Sep, 2021
  • 105 locations
None
Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

This randomized phase III trial studies how well imatinib mesylate and combination chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, work …

cytarabine
shortening fraction
doxorubicin
methotrexate
glomerular filtration rate
  • 305 views
  • 02 Sep, 2021
  • 188 locations
None
Remote Ischaemic Preconditioning in Childhood Cancer

focused on changing the formulation or rate of administration of anthracyclines but with no observable benefits. While dexrazoxane, an iron chelator, has shown to reduce cardiotoxic outcomes, there

troponin
myocardial injury
metastasis
anthracyclines
cancer
  • 0 views
  • 07 May, 2021
  • 2 locations
None
Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic Osteosarcoma

Preclinical models show that a daily antiangiogenic regimen at low-dose may be effective against chemotherapy-resistant tumors. The aim of this study is to evaluate the efficacy of maintenance therapy with continuous oral cyclophosphamide and methotrexate in patients with high grade, operable, metastatic osteosarcoma (OST) of the extremities. The primary end …

cancer chemotherapy
cancer
metastatic osteosarcoma
methotrexate
  • 58 views
  • 21 Jan, 2021
  • 1 location
None
Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage

The purpose of this study is to test the safety and determine the best dose of venetoclax and cytarabine when given with or without idarubicin in treating pediatric patients with acute myeloid leukemia (AML) that did not respond to treatment (refractory) or has come back after treatment (relapsed). PRIMARY OBJECTIVE: …

azacitidine
cytarabine
idarubicin
ejection fraction
graft versus host disease
  • 107 views
  • 25 Jun, 2021
  • 4 locations
None
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the

angiotensin
anthraquinone
chemotherapy regimen
doxorubicin
remission
  • 52 views
  • 05 Aug, 2021
  • 42 locations