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Found 23 clinical trials
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory desmoplastic small

vinorelbine
desmoplastic
measurable disease
kidney function tests
immunomodulators
  • 4 views
  • 23 Jul, 2022
  • 55 locations
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 488 views
  • 06 May, 2022
  • 16 locations
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum

The purpose of this study is to test any good and bad effects of the study drug 131I-omburtamab. 131I-omburtamab could prevent the cancer from returning, or delay the cancer from getting worse, but it could also cause side effects. Researchers hope to learn more about how 131I-omburtamab works in the …

desmoplastic
cancer chemotherapy
cancer
tumor progression
  • 24 views
  • 14 Jun, 2022
  • 1 location
Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

This is a first-in-human, Phase 1/2 open-label, multicenter, dose-escalation, safety, PK, and biomarker study of PBI-200 in subjects with NTRK-fusion-positive advanced or metastatic solid tumors.

measurable disease
systemic therapy
NTRK
  • 13 views
  • 11 Aug, 2022
  • 11 locations
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

This phase II trial investigates side effects and how well donor stem cell transplant after chemotherapy works in treating pediatric and adolescent-young adults with high-risk solid tumor that has come back (recurrent) or does not respond to treatment (refractory). Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte …

neuroectodermal tumor
melphalan
solid tumor
glomerular filtration rate
malignant peripheral nerve sheath tumor
  • 0 views
  • 15 Jul, 2022
Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas

and cohort C: Small round-cell sarcomas (Ewing's sarcoma, rhabdomyosarcoma, desmoplastic small round-cell tumors and other small round cell sarcomas)) with 7 sites in Spain. Main objective: To

soft tissue sarcoma
desmoplastic
measurable disease
anthracyclines
systemic therapy
  • 0 views
  • 13 Dec, 2021
  • 11 locations
Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Single agent, non-randomized, open label expansion in select sarcoma patients including myxoid liposarcoma and other sarcomas that share similar chromosomal translocations to Ewing sarcoma; AND dose expansion of the combination of seclidemstat with topotecan and cyclophosphamide in patients with Ewing sarcoma

liposarcoma
ct scan
measurable disease
myxoid liposarcoma
refractory ewing sarcoma
  • 92 views
  • 26 Mar, 2022
  • 13 locations
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients (PIPER)

This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma. The aim of this study is to implement high-throughput profiling technologies to identify predictive biomarkers of trabectedin efficacy through sequential tumor biopsies and blood sample collection in sarcoma …

epithelioid sarcoma
liposarcoma
measurable disease
hemangioendotheliomas
metastasis
  • 0 views
  • 22 Mar, 2022
  • 1 location
Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for the Treatment of Resectable, Refractory, or Recurrent Abdominal or Pelvic Tumors in Pediatric Patients, T.O.A.S.T. I.T. Study

This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (refractory), or has come back (recurrent). Heated intra-peritoneal chemotherapy is a procedure performed in …

fallopian tube
measurable disease
lactate dehydrogenase
renal function
prothrombin
  • 1 views
  • 25 May, 2022
  • 1 location
Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group (MIRAS)

This trial is a translational, open-label, multi-sites, prospective and retrospective cohort study of 500 patients aimed at clinical and biological characterization of sarcoma of rare subtype. 400 patients will be included in this prospective cohort study; they will be identified in the investigating centers in the context of either routine …

soft tissue sarcoma
epithelioid sarcoma
desmoplastic
alveolar soft part sarcoma
fibrosarcoma
  • 0 views
  • 09 Aug, 2022
  • 10 locations