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Found 22 clinical trials
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CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory desmoplastic small

neutrophil count
kidney function tests
cancer
desmoplastic
cancer chemotherapy
  • 4 views
  • 16 Jan, 2022
  • 69 locations
None
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 487 views
  • 28 Apr, 2021
  • 17 locations
None
A Study of the Drugs Prexasertib Irinotecan and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

The purpose of this study is to test whether the study drug prexasertib is a safe and effective treatment for people with DSRCT or RMS when given in combination with the standard drugs irinotecan and temozolomide. The study will test different doses of prexasertib in combination with irinotecan and temozolomide …

schwartz
antineoplastic
renal function
neutrophil count
myelosuppressive chemotherapy
  • 7 views
  • 10 Oct, 2021
  • 1 location
None
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum

The purpose of this study is to test any good and bad effects of the study drug 131I-omburtamab. 131I-omburtamab could prevent the cancer from returning, or delay the cancer from getting worse, but it could also cause side effects. Researchers hope to learn more about how 131I-omburtamab works in the …

tumor progression
cancer
desmoplastic
cancer chemotherapy
  • 24 views
  • 17 Nov, 2021
  • 2 locations
None
Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

This is a first-in-human, Phase 1/2 open-label, multicenter, dose-escalation, safety, PK, and biomarker study of PBI-200 in subjects with NTRK-fusion-positive advanced or metastatic solid tumors.

measurable disease
systemic therapy
NTRK
  • 13 views
  • 28 Oct, 2021
  • 7 locations
None
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

This phase II trial investigates side effects and how well donor stem cell transplant after chemotherapy works in treating pediatric and adolescent-young adults with high-risk solid tumor that has come back (recurrent) or does not respond to treatment (refractory). Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte …

etoposide
stem cell transplant
primitive neuroectodermal tumor
desmoplastic
cancer chemotherapy
  • 0 views
  • 03 Mar, 2021
None
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients

This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma. The aim of this study is to implement high-throughput profiling technologies to identify predictive biomarkers of trabectedin efficacy through sequential tumor biopsies and blood sample collection in sarcoma …

hemangioendotheliomas
epithelioid sarcoma
measurable disease
trabectedin
desmoplastic
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas

and cohort C: Small round-cell sarcomas (Ewing's sarcoma, rhabdomyosarcoma, desmoplastic small round-cell tumors and other small round cell sarcomas)) with 7 sites in Spain. Main objective: To

neutrophil count
soft tissue sarcoma
ewing's sarcoma
desmoplastic
metastasis
  • 0 views
  • 13 Dec, 2021
  • 11 locations
None
Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for the Treatment of Resectable Refractory or Recurrent Rhabdomyosarcoma in Pediatric Patients T.O.A.S.T. I.T. Study

This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (refractory), or has come back (recurrent). Heated intra-peritoneal chemotherapy is a procedure performed in …

lactate dehydrogenase
neutrophil count
renal function
thromboplastin
metastasis
  • 0 views
  • 04 Feb, 2021
  • 1 location
None
Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group

This trial is a translational, open-label, multi-sites, prospective and retrospective cohort study of 500 patients aimed at clinical and biological characterization of sarcoma of rare subtype. 400 patients will be included in this prospective cohort study; they will be identified in the investigating centers in the context of either routine …

epithelioid sarcoma
alveolar soft part sarcoma
fibrosarcoma
soft tissue sarcoma
desmoplastic
  • 0 views
  • 10 Oct, 2021
  • 10 locations