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Found 13 clinical trials
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.

anaplastic large cell lymphoma
phenytoin
small molecule
fibrosarcoma
chemotherapy regimen
  • 281 views
  • 26 Jan, 2021
  • 12 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)

choriocarcinoma
immunosuppressive agents
mullerian mixed tumor
germ cell tumor of ovary
pancreatic adenocarcinoma
  • 6048 views
  • 24 Sep, 2021
  • 818 locations
Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis

In this study Drug-eluting microbeads (DEB) loaded with Doxorubicin will be delivered into the target Desmoid Fibromatoses (DF) tissue via selective arterial embolization by angiographic

methotrexate
measurable disease
colony stimulating factors
myelosuppressive chemotherapy
nonsteroidal anti-inflammatory drugs
  • 17 views
  • 23 Jan, 2021
  • 1 location
A Study of AL102 in Patients With Progressing Desmoid Tumors

The current study is designed to evaluate the efficacy and safety of AL102 in patients with progressive desmoid tumors.

measurable disease
line of therapy
MRI
  • 0 views
  • 10 Sep, 2021
  • 10 locations
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor

This is a phase I/II, open-label, non-randomized, multicentre study to evaluate the clinical activity of vactosertib plus imatinib in desmoid tumor. Based on the background, TGFinhibition as a

measurable disease
vactosertib
ejection fraction
imatinib
fibromatosis
  • 45 views
  • 01 May, 2021
  • 1 location
A Study of a New Drug Nirogacestat for Treating Desmoid Tumors That Cannot be Removed by Surgery

This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of

tyrosine
NSAID
neutrophil count
stroke
cardiac dysrhythmias
  • 0 views
  • 12 Sep, 2021
  • 42 locations
Talimogene Laherparepvec Nivolumab and Trabectedin for Sarcoma

This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

advanced sarcoma
measurable disease
kidney function tests
metastatic sarcoma
trabectedin
  • 1 views
  • 26 Aug, 2021
  • 1 location
Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors

therapy on the 3 years rate of local tumor recurrence in patients with desmoid tumors. To evaluate the Safety of 5-ALA administration. 5 years local recurrence rate.

  • 39 views
  • 08 Nov, 2020
  • 1 location
Nivolumab (Opdivo ) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

sarcoma, PEComa, epithelioid sarcoma, desmoid tumor, chordoma, non-small cell lung cancer, small cell lung cancer, urethelial carcinoma, melanoma, renal cell carcinoma, squamous cell carcinoma of head and

pd-1 inhibitor
secondary malignant neoplasm of liver
msi-h
chordoma
squamous cell carcinoma of head and neck
  • 82 views
  • 15 May, 2021
  • 1 location
MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors

The purpose of this study is to determine if Magnetic Resonance guided High Intensity Focused Ultrasound ablative therapy is safe and feasible for children, adolescents, and young adults with refractory or relapsed solid tumors.

tyrosine
graft versus host disease
colony-stimulating factors
kidney function tests
hifu
  • 274 views
  • 07 Aug, 2021
  • 2 locations