Found 13 clinical trials
A Study of AL102 in Patients With Progressing Desmoid Tumors (RINGSIDE)
The current study is designed to evaluate the efficacy and safety of AL102 in patients with progressive desmoid tumors.
- 11 views
- 01 Jul, 2022
- 27 locations
A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery
This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of
- 0 views
- 10 Aug, 2022
- 51 locations
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies
This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.
- 286 views
- 25 Mar, 2022
- 14 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)
- 6634 views
- 10 Aug, 2022
- 752 locations
Cryotherapy in the Treatment of Desmoid Tumors
Desmoid tumor is a benign neoplasm with an unpredictable course and a high rate of local recurrence if treated surgically. Therefore, over time the surgical approach has become conservative
- 0 views
- 22 Apr, 2022
- 1 location
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of …
- 0 views
- 09 May, 2022
- 10 locations
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor
This is a phase I/II, open-label, non-randomized, multicentre study to evaluate the clinical activity of vactosertib plus imatinib in desmoid tumor. Based on the background, TGF-β inhibition as
- 46 views
- 02 Jul, 2022
- 1 location
Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma (TNT)
This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.
- 37 views
- 08 Feb, 2022
- 1 location
Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors
therapy on the 3 years rate of local tumor recurrence in patients with desmoid tumors. To evaluate the Safety of 5-ALA administration. 5 years local recurrence rate.
- 39 views
- 08 Nov, 2020
- 1 location
HIFU Ablation of Soft Tissue Sarcoma (SarcAblate)
> This study will recruit patients with both resectable and unresectable STS, in addition to unresectable small symptomatic desmoid tumours. 12-16 patients, and a minimum of 10 patients with
- 0 views
- 21 Mar, 2022
- 1 location
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