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Found 69 clinical trials
Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

Background Electroconvulsive therapy (ECT) is used to treat people with severe depression. During ECT, the brain is given electric pulses that cause a seizure. Although it is effective, it can cause side effects, including memory loss. Researchers want to study a new way to give ECT called iLAST. Objective To …

anesthesia
electroconvulsive therapy
depressed mood
depressive disorder
scid
  • 6 views
  • 19 Sep, 2021
  • 1 location
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

Background Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. It stimulates the brain. Researchers want to see if using magnetic resonance imaging (MRI) scans helps locate the best area for rTMS in each person. They also want to find other ways to make it more effective. Objective To …

anxiety
transcranial magnetic stimulation
depressive symptoms
MRI
cognitive therapy
  • 67 views
  • 19 Sep, 2021
  • 1 location
Digital Game: A Scale to Evaluate the Perioperative Cognitive Function

INTRODUCTION: Cognitive dysfunction is a frequent adverse event in the postoperative period, especially in elderly patients. The tests commonly used for the detection of postoperative cognitive dysfunction are time-consuming and with variable sensitivity and specificity and difficult routine use. Applying a difficult battery of cognitive tests decreases the viability of …

cancer
cognitive impairment
postoperative cognitive dysfunction
diabetes
hypertension
  • 0 views
  • 24 Jan, 2021
  • 1 location
Effects of the Transcranial Stimulation on Prevention of Cognitive Dysfunction in Cardiac Surgery

Postoperative cognitive dysfunction (POCD) is a contrary event observed between 20 to 83%, especially on elderly and patients submitted to cardiac surgery. The prevention and rehabilitation on cases of POCD can improve the quality of life and decrease the mortality in surgical patients. The effect of the noninvasive cerebral stimulation, …

heart surgery
cognitive impairment
brain injury
depression
  • 12 views
  • 25 Jan, 2021
  • 1 location
Antidepressant Trial With P2X7 Antagonist JNJ-54175446

Depression is one of the most important causes of disability in the world today, with major personal, social and economic costs. Although some moderately effective drug treatments are already available, about a third of patients with major depressive disorder (MDD) remain depressed despite current treatment. There is growing evidence that …

depressed mood
electrocardiogram
depression
12 lead ECG
  • 4 views
  • 06 Aug, 2021
  • 5 locations
rTMS Response Trajectories in Depression

Previous studies on network mechanism of repetitive transcranial magnetic stimulation (rTMS) suggest that pretreatment resting-state functional magnetic resonance imaging (rs-fMRI) connectivity may serve as a predictive biomarker for antidepressant treatment response. In phase I of the study, the focus was on the predictive value of pretreatment connectivity between the left …

psychiatric disorder
major depressive disorder
antidepressants
hdrs
depressed mood
  • 8 views
  • 24 Jan, 2021
  • 1 location
The RECOVER sUb-study Which Leverages quaNtitative and Credible Research tOols From Verily Will providE Assessment measuRes for Depressive Episodes

The objective of this study is to collect both active and passive data using a wearable, multi-sensor device (Verily Study Watch) and phone application (Mood App) which aims to capture mental health status, in subjects participating in the RECOVER clinical trial (A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the …

  • 0 views
  • 22 Aug, 2021
  • 20 locations
Outcomes Associated With Suicidality in Inpatients With Symptoms of Depression (OASIS-D)

This 6-month, naturalistic cohort study examines male and female inpatients aged 18 to 75 years i) with any form of unipolar depressive episode (cohort 1); ii) clinical diagnosis of a moderate

suicidal
depressive episode
depressed mood
depressive disorder
depressive symptoms
  • 0 views
  • 27 May, 2021
  • 1 location
University of Iowa Interventional Psychiatry Service Patient Registry

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or …

electroconvulsive therapy
depressed
depressed mood
transcranial magnetic stimulation
ketamine
  • 0 views
  • 18 Apr, 2021
  • 1 location
Youth Depression and Suicide Research Network

The objective of this study is to build the Texas Youth Depression and Suicide Research Network to support the development of a Network Participant Registry and characterization of systems and interventions to examine statewide population health outcomes. All 12-13 sites represented in the Texas Child Mental Health Care Consortium (https://www.utsystem.edu/pophealth/tcmhcc/) …

suicide
suicidal
depressed mood
depression
  • 0 views
  • 23 Jun, 2021
  • 1 location