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Found 69 clinical trials
Development and Evaluation of Culturally Adapted CBT for South Asian Canadians

As CBT was developed for persons from North America and European background it needs to be adapted for persons from non-Western cultures. This mixed methods study proposes a culturally adapted Cognitive Behavioural Therapy (CA-CBT) model for Canadians of South Asian origin. Beginning with a participatory/qualitative research approach, common themes amongst …

behavior therapy
depressed mood
anxiety
  • 0 views
  • 09 Aug, 2021
  • 3 locations
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth

A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder. Subjects will be evaluated using semi-structured diagnostic interviews and symptom ratings, participate in a MRI scan and then randomized to treatment. Following randomization, high-risk youth will have visits every …

depression
structured clinical interview
behavior therapy
bipolar disorder
anxiety
  • 351 views
  • 08 Jul, 2021
  • 2 locations
Group Intervention to Improve Parent-Adolescent Relationships

This pilot randomized control trial investigates whether a psychosocial intervention targeting parent-adolescent conflict is feasible and acceptable, in preparation for a future trial that will test whether the intervention can improve treatment outcomes for youth diagnosed with depression.

depressive disorder
depressed mood
  • 0 views
  • 19 Sep, 2021
  • 1 location
Telephone-administered Relapse Prevention for Depression

This study determines the effectiveness of telephone-delivered cognitive-behavioral continuation therapy (T-CT) in comparison to usual care in people with recurrent or chronic depression. The primary research question is whether participating in T-CT reduces depressive relapses. The continuation therapy comprises eight therapy sessions delivered over the telephone by a trained therapist …

depression
psychiatric disorder
depressive episode
major depressive disorder
psychotherapy
  • 31 views
  • 21 Jul, 2021
  • 23 locations
Measuring Blood Flow in the Brain After Epileptic Activity

In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT). Postictal phenomena are thought to result from decreased cerebral blood flow and decreased oxygen concentration in the brain. It is expected that acetaminophen and nimodipine …

electroconvulsive therapy
depressed mood
depressive episode
  • 0 views
  • 22 Sep, 2021
  • 1 location
Lithium and Standard Therapy in Resistant Depression

The principal clinical question is whether lithium is effective in reducing the risk of suicidal behaviour in subjects with treatment-resistant depression and suicide risk. Additionally aims of the study are: (a) to assess whether lithium is effective in improving depressive symptomatology in subjects with treatment-resistant depression and suicide risk; (b) …

lithium
suicidal
antidepressants
suicide
depressive episode
  • 0 views
  • 07 Nov, 2020
  • 1 location
Ketamine Alcohol (in Treatment-Resistant Depression)

A single subanesthetic dose infusion of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and robust antidepressant effects in patients with treatment-refractory major depressive disorder (TRD). A family history of an alcohol use disorder (Family History Positive, FHP) is one of the strongest identified predictors of an improved antidepressant response …

ketamine
depression
major depressive disorder, single episode
substance use
depressive episode
  • 57 views
  • 25 Jan, 2021
  • 2 locations
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.

The hypothesis of a link between depression and Hypothalamic-Pituitary Axis (HPA) dysfunction is now experienced. Since a first description in 1949 this link has made the HPA one of the most investigated hormonal axis in depression. Many studies have demonstrated quantitative variations of circulating cortisol in situation of depression including …

depression
depressive episode
suicidal
corticotropin
norepinephrine
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Psychoeducation Programmes - Patients With Bipolar Disorder

This is a controlled, randomized, prospective, open-label, non-inferiority trial lasting 12 months. The effectiveness of using a psychoeducational smartphone application (SIMPLe) will be compared to the effectiveness of face-to-face group psychoeducation.

  • 0 views
  • 11 Mar, 2021
  • 10 locations
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

We propose a clinical study of medial forebrain bundle DBS as a treatment in 10 patients with treatment refractory depression (TRD). Data from the University of Bonn indicates that surgical lesions of the medical forebrain bundle can produce therapeutic benefits in patients with depressive disorders, and suggest that DBS at …

depression
antipsychotics
suicidal
major depressive disorder
structured clinical interview
  • 247 views
  • 29 Jun, 2021
  • 1 location