Found 64 clinical trials
Researching the effectiveness of cariprazine for treatment of depressive episodes in patients with bipolar disorder.
Researching the effectiveness of cariprazine for treatment of depressive episodes in patients with bipolar disorder.
- 320 views
- 23 Nov, 2020
- 1 location
A Study of JNJ-55308942 in the Treatment of Bipolar Depression
The purpose of this study is to evaluate the efficacy of JNJ-55308942 compared to placebo on symptoms of depression in participants with bipolar disorder (BD) in a major depressive episode (MDE
- 42 views
- 07 Apr, 2023
- 32 locations
Clinical Evaluation of the Antidepressant Effect of the Use of Probiotics in Bipolar Disorder
Bipolar Disorder (BD) is highly incapacitating and associated with premature mortality. Depressive symptoms and episodes are the most frequent cause of disability in subjects with BD and over half of patients do not respond adequately to approved treatments for this condition, showing the need for new classes of treatments to …
- 0 views
- 11 Apr, 2023
- 1 location
bBeAMom: Effectiveness of a Cognitive-Behavioral Blended Intervention for Postpartum Depression (bBeAMom)
Be a mom program (a web-based cognitive-behavioral intervention) is being tested in another clinical trial as a preventive intervention for postpartum depression (NCT03024645). However, given its effectiveness in reducing depressive symptoms among women presenting early-onset postpartum depressive symptoms, Be a Mom can also have potential as a postpartum depression complement …
- 0 views
- 04 Oct, 2022
- 1 location
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression (EPIsoDE)
The study aims to investigate the safety and efficacy of oral psilocybin administered under supportive conditions in treatment-resistant major depression (TRD). The study is a bi-centric, prospective, randomized, active placebo-controlled study investigating the effects of 25 mg and 5 mg (p.o.) psilocybin versus placebo (100 mg nicotinamide) in a psychotherapeutic …
- 1 views
- 10 Apr, 2023
- 1 location
A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.
A clinical trial to study the efficacy and safety of an investigational drug in people with major depressive episodes associated with with Bipolar I disorder (bipolar I depression) Participants in the study will either receive the drug being studied or a placebo. The study will be conducted in approximately 90 …
- 57 views
- 11 Apr, 2023
- 68 locations
Optimal Electrical Stimulus During Electroconvulsive Therapy
, 400 patients in each arm. Inclusion criteria: At least 18 years of age at the time of inclusion Diagnostic criteria fulfilled for unipolar, or bipolar depressive episode according to
- 122 views
- 16 Feb, 2022
- 1 location
Multi-factor Model Constraction for Early Warning and Diagnosis of MDD
Current research on the pathogenesis of depression shows that imbalanced inflammatory factors are closely related to Major Depressive Disorder(MDD). As reported, physical exercise, Ω-3 fatty acids, and sulforaphane can be complementary therapies for moderate-to-severe depression. In addition, imaging studies have found changes in the structure and functional connectivity of the …
- 0 views
- 07 Oct, 2022
- 1 location
Cerebral Neuroinflammation During Major Depressive Episode (InflaDep)
the investigators make the following assumptions: 1) neuroinflammation in MDD can be measured by the [18 F ] DPA- 714 ; 2) it is accompanied by anatomical and functional changes in the frontal subcortical loops, strongly involved in MDD ; 3) neuroinflammation in patients might be a biomarker related to …
- 7 views
- 11 Apr, 2023
- 3 locations