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Found 2747 clinical trials
Nutrition and Inflammation in Patients With Head and Neck Cancer

An estimated 1500 people in Sweden will annually be diagnosed with head and neck cancer (HNC). Five year survival is approximately 69%. Long-term sequelae are common and in particular nutritional problems and fatigue. Radiotherapy (RT) is the cornerstone of treatment, either as single modality treatment or combined modality treatment. RT …

head and neck cancer
nutritional problems
neck cancer
  • 29 Oct, 2021
  • 1 location
Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

Patients taking thyroid hormone replacement after thyroid removal surgery often report feeling differently than they did prior to taking thyroid hormone. The symptoms can include fatigue, worsening mood or subjective "brain fog" where the patient feels like their thinking is just not as sharp as it was previously. Multiple studies …

levothyroxine therapy
thyroid hormones
replacement therapy
  • 24 Feb, 2022
  • 1 location
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery

Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood. Primary failure of neural tube closure at the caudal neuropore in the embryonic period results in exposure of the developing spinal …

Accepts healthy volunteers
  • 13 Feb, 2022
  • 1 location
Sirolimus Eluting Balloon Utilization for Treatment of Vasculogenic Erectile Dysfunction (SUASION)

Brief Summary: Background and pathophysiology: Erectile dysfunction (ED) is defined as the recurrent inability to achieve and maintain an erection satisfactory for sexual intercourse. ED is not in itself a "serious" disease, but its impact on quality of life is extremely important, affecting the family and interpersonal relationships. Male erection …

vasculogenic erectile dysfunction
  • 04 Mar, 2022
Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

This study is designed to find behavioral and neurophysiological correlates of pain avoidance behavior among chronic pain patients, controlling for risk for opioid use disorder. Further, traits and risk factors that contribute to pain avoidance behavior will be investigated. The knowledge gained will broaden the current understanding of mechanisms involved …

chronic pain
  • 23 Mar, 2022
  • 1 location
CGRP Inhibition, Autonomic Function, and Migraine (CGRP-1)

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location
Fever of Unknown Origin (FUO) in Elderly Patients

Objective: Fever of unknown (FUO) origin remains challenging in geriatric patients. Geriatric patients have a blunted immune response responsible for altered fever mechanisms and immune cells responses. Consequently, FUO could be inappropriately named and could be changed in Inflammation of unknown origin (IUO) in this specific population. Furthermore, the studies …

  • 06 Dec, 2021
  • 1 location
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain

Chronic pain affects nearly 20% of Canadians, and sixty percent or more of individuals with chronic pain are also struggling with mental health or substance use disorders (referred to as complex chronic pain, or CCP, patients). This is a major concern in the best of times and has become an …

behavior therapy
depressive symptoms
chronic pain
  • 10 Oct, 2021
  • 1 location
BEAM: Brain-Eye Amyloid Memory Study (BEAM)

The main objectives for this study are: To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative dementias against standard cognitive assessments and brain imaging measures; and To assess the potential utility of ocular assessments for early detection …

functional imaging
brain imaging
parkinson's disease
optical coherence tomography
  • 25 Jan, 2022
  • 5 locations
Innovative Approach to Triage Oral Precancer

Oral cancer is a major health problem worldwide, accounting for 274,000 new cases and 145,000 deaths annually. On average, half of the patients die within 5 years of an oral cancer diagnosis. Most troubling, however, is the lack of significant change in prognosis for this disease over the last 4 …

  • 21 Jan, 2021
  • 1 location