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Found 403 clinical trials
Featured trial
Ketamine for the Treatment of Depression in Parkinson's Disease (KET-PD)

The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density …

depressive disorder
ketamine
depression
hoehn and yahr scale
depressed mood
  • 41 views
  • 07 Oct, 2022
  • 1 location
Featured trial
Cognitive Fitness for Depression in Older Adults

This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance …

  • 81 views
  • 22 Jan, 2022
  • 1 location
Featured trial
Depression

> Research is needed to find new, more effective, faster-acting treatment options with fewer side effects. People with MDD experience a depressed mood (persistent feelings of sadness

treatment resistant depression
transcranial magnetic stimulation
depressive disorder
behavior therapy
suicidal
  • 137 views
  • 30 Jul, 2021
  • 1 location
Featured trial
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder

  • 112 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Clinical trial measuring efficacy of Vortioxetine for relapse prevention in adults with MDD

Clinical trial measuring efficacy of Vortioxetine for relapse prevention in adults with MDD

  • 100 views
  • 23 Nov, 2020
  • 1 location
Valuation in Depressed Mood, Anhedonia, and Anxiety

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety

  • 0 views
  • 02 Jun, 2022
  • 1 location
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement (CRC289A07)

(fully crossed 2x2 placebo design) before performing a probabilistic reinforcement learning task, an effort expenditure task, and undergo a depressed mood induction procedure. Further, EEG indices will

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
bBeAMom: Effectiveness of a Cognitive-Behavioral Blended Intervention for Postpartum Depression (bBeAMom)

Be a mom program (a web-based cognitive-behavioral intervention) is being tested in another clinical trial as a preventive intervention for postpartum depression (NCT03024645). However, given its effectiveness in reducing depressive symptoms among women presenting early-onset postpartum depressive symptoms, Be a Mom can also have potential as a postpartum depression complement …

behavior therapy
anxiety
depressive episode
depressive symptoms
depressed mood
  • 0 views
  • 04 Oct, 2022
  • 1 location
Personalized Prevention of Depression in the Workplace (e-pD-Work)

The main goal is to design, develop and evaluate a personalized intervention to prevent depression in the workplace, based on Information and Communication Technologies (ICTs), predictive risk algorithms and decision support systems (DSS) for employed workers. The specific goals are: 1) to design and develop a DSS, called e-predictD-Work-DSS to …

anxiety
depressed mood
  • 0 views
  • 04 Sep, 2021
  • 1 location
Implementation Strategies for Task-Shifting Depression Care Depression Care in Vietnam

The study is a Hybrid Implementation-Effectiveness study that will primarily test the implementation strategies on provider adoption and implementation quality in three Vietnam provinces. Secondarily, the effectiveness of the multicomponent collaborative care model for depression intervention on patient outcomes will be tested. A cluster randomized control trial design, with a …

depressed mood
  • 0 views
  • 09 May, 2022
  • 1 location