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Found 66 clinical trials
Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis (CAVS-MS)

The need for improved diagnostic methods in Multiple Sclerosis (MS) is widely recognized. Although Magnetic Resonance Imaging (MRI) is a longstanding tool for detecting MS lesions, diagnostic inaccuracies persist. Up to 20% of people diagnosed with MS (1 in 5) are later found not to have the disease. This is …

optic neuritis
MRI
disease or disorder
fatigue
weakness
  • 110 views
  • 22 Apr, 2022
  • 11 locations
NT-3 Levels and Function in Individuals With CMT

This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.

peripheral neuropathy
nerve conduction studies
type 2 diabetes
diagnostic tests
nerve conduction
  • 8 views
  • 27 Aug, 2021
  • 1 location
Biorepository and Registry for Plasma Exchange Patients

Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies. At our facility about 400 of these procedures are performed annually on 40-60 different patients. These procedures are considered within the standard of care for these patients and are …

plasma exchange
immune globulin
cell counts
  • 3 views
  • 22 Aug, 2021
  • 1 location
Biomarkers in Polyradiculoneuropathies (BIP)

The nodes of Ranvier contain ion channels that enable the rapid propagation of the nerve impulse. Cell adhesion molecules and glycolipids play an important role in the formation of the nodes of Ranvier. Antibodies against glycolipids are detected in half of patients with Guillain-Barr syndrome, an acute inflammatory neuropathy affecting …

cell adhesion molecules
polyradiculoneuropathy
inflammatory neuropathy
neuromuscular diseases
adhesion
  • 59 views
  • 24 Feb, 2022
  • 1 location
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment

In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment with Ofatumumab (Kesimpta®) will be less toxic to mouse-derived oligodendrocyte lineage cells, grown in a dish, than …

disease or disorder
neurological disorder
Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. (SONICS)

Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI …

transverse myelitis
demyelination
multiple sclerosis
encephalomyelitis
neuritis
  • 0 views
  • 09 Aug, 2022
  • 1 location