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Found 69 clinical trials
Ccf mtDNA as a Neurodegenerative Biomarker

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. One of the most critical factors in biomarker research is the inadequate linkage of biological samples with data from …

cancer
Accepts healthy volunteers
multiple sclerosis
stroke
  • 3 views
  • 16 May, 2022
  • 1 location
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which we believe is detrimental to MS. We will examine clinical data (MRI, lab results, medical history, labs, and sleep studies) of Dr. Sloane's MS patients. …

MRI
  • 0 views
  • 26 Jan, 2021
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions

We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research. We make it easy for patients to contribute to research for medical conditions that matter most to them, regardless of their location or ability to travel.

Accepts healthy volunteers
  • 261 views
  • 26 Jan, 2022
  • 1 location
Gray Matter Demyelination in Primary Progressive MS at 7T

'normal appearing' cortical damage in PPMS. This will answer relevant questions about the brain's capacity for repair, the extent of demyelination and the occurrence of inherent cortical remyelination and

Accepts healthy volunteers
  • 0 views
  • 16 Jun, 2022
  • 1 location
Magnetic Resonance Imaging Study on Patients With Hemifacial Spasm (MRI-HFS)

abnormalities, such as axonal loss, demyelination, collagen deposition, etc. In this study, cross-sectional area (CSA) and volume (V) of the cisternal facial nerve will be assessed to determine whether it can

  • 25 views
  • 27 May, 2022
  • 1 location
DreaMS - Validation Study 1

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) causing focal lesions of demyelination and diffuse neurodegeneration in the grey and white matter of

Accepts healthy volunteers
  • 0 views
  • 30 Jun, 2022
Natural History Study of Patients With Canavan Disease

This study will use medical records that will allow retrospective data extraction of critical milestone and motor function data. In addition, prospective assessments will collect data relevant to the natural history of Canavan disease in children.

  • 3 views
  • 14 May, 2022
  • 1 location
Prognostic Value of Cerebrospinal Fluid Immunoglobulin Free Light Chains in Patients With Multiple Sclerosis

explore its potential correlation with in vivo measures of demyelination and neuronal and axonal loss after ON, as model of potential recovery after MS relapse. The investigators aim also to compare the

clinically isolated syndrome
brain mri
optical coherence tomography
fatigue
optic neuritis
  • 0 views
  • 19 Oct, 2021
  • 1 location
Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia (MATRIX)

This study is a national, non-randomized, open-label, multi-site with minimal risk study in adult with adrenomyeloneuropathy (AMN), childhood and adult subjects with cerebral ALD (cALD), juvenile/adult metachromatic leukodystrophy (MLD) and adults with leukoencephalopathy and axonal spheroids and pigmented glia (ALSP). 49 subjects will be enrolled with one blood sample collection …

Accepts healthy volunteers
  • 0 views
  • 15 May, 2022
  • 1 location
Exercise and Pregnancy in People With Multiple Sclerosis

The purpose of this study is to examine acute physiological responses to exercise and activity patterns of people with multiple sclerosis (MS) during pregnancy and postpartum.

Accepts healthy volunteers
  • 0 views
  • 24 Apr, 2022
  • 1 location