Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 63 clinical trials
None
Disability MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination

Knowledge of the evolution of multiple sclerosis (MS) and its long-term prognostic factors is essential to guide the therapeutic management. However, it remains partial and concerns above all data collected during the first years of the disease. The evolution towards disability can only be assessed after a follow-up of more …

optical coherence tomography
demyelination
atrophy
disease or disorder
MRI
  • 0 views
  • 22 Jul, 2021
  • 1 location
None
Magnetic Resonance Imaging Study on Patients With Hemifacial Spasm

abnormalities, such as axonal loss, demyelination, collagen deposition, etc. In this study, cross-sectional area (CSA) and volume (V) of the cisternal facial nerve will be assessed to determine whether it can

  • 0 views
  • 19 Feb, 2021
  • 1 location
None
Natural History Study of Patients With Canavan Disease

This study will use medical records that will allow retrospective data extraction of critical milestone and motor function data. In addition, prospective assessments will collect data relevant to the natural history of Canavan disease in children.

  • 3 views
  • 16 Aug, 2021
  • 2 locations
None
Prognostic Value of Cerebrospinal Fluid Immunoglobulin Free Light Chains in Patients With Multiple Sclerosis

explore its potential correlation with in vivo measures of demyelination and neuronal and axonal loss after ON, as model of potential recovery after MS relapse. The investigators aim also to compare the

demyelination
oligoclonal bands
disease or disorder
clinically isolated syndrome
optic neuritis
  • 0 views
  • 19 Oct, 2021
  • 1 location
None
Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy and Metachromatic Leukodystrophy

This study is a national, non-randomized, open-label, multi-site with minimal risk study in adult with adrenomyeloneuropathy (AMN) and childhood subjects with cerebral ALD (cALD) or late-infantile metachromatic leukodystrophy (LI-MLD) (17 years). 28 subjects will be enrolled with one blood sample collection during one of their medical follow-up visit. This trial …

  • 0 views
  • 30 Sep, 2021
  • 1 location
None
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy

The purpose of the study is to systematically characterize the clinical course of the progressive neuropathy and optic atrophy observe in pediatric and adult patients with biallelic mutations in the solute carrier family 25 member 46 (SLC25A46) gene.

  • 0 views
  • 08 Sep, 2021
  • 1 location
None
Microstructure Imaging in Stroke Patients

The purpose of this study is to establish a methodological framework based on existing advanced neuroimaging technologies as a new clinical neuroimaging tool for assessment of possible affected brain connections in stroke and TIA patients. Thus, providing new insights into microstructural changes that may underline why those patients experience deficits …

stroke
  • 0 views
  • 16 Apr, 2021
  • 2 locations
None
Predictors and Prognostic Factors of Gullian Barrie Syndrome Outcome

This study aims to identify clinical and biological determinants and factors that predict outcome including primary outcome (percentage of changes in clinical scales pre- and after 3 months ) and secondary outcome depending on neurophysiologiacal studies and prognostic factors in individual patients with Guillain-Barre syndrome i individuals managed by plasmapheresis …

  • 0 views
  • 14 Aug, 2021
  • 1 location
None
Biomarkers in Polyradiculoneuropathies

The nodes of Ranvier contain ion channels that enable the rapid propagation of the nerve impulse. Cell adhesion molecules and glycolipids play an important role in the formation of the nodes of Ranvier. Antibodies against glycolipids are detected in half of patients with Guillain-Barr syndrome, an acute inflammatory neuropathy affecting …

neuromuscular diseases
inflammatory neuropathy
cell adhesion molecules
polyradiculoneuropathy
adhesion
  • 53 views
  • 24 Jan, 2021
  • 1 location
None
NT-3 Levels and Function in Individuals With CMT

This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.

peripheral neuropathy
diabetes
nerve conduction
polyneuropathy
nerve conduction studies
  • 0 views
  • 27 Aug, 2021
  • 1 location